Literature DB >> 10474654

Wall shear stress in backward-facing step flow of a red blood cell suspension.

F J Gijsen1, F N van de Vosse, J D Janssen.   

Abstract

An experimental investigation of the wall shear stress distribution downstream of a backward-facing step is carried out. The wall shear stress distribution was determined by measuring the deformation of a gel layer, attached to the wall downstream of the step. Speckle pattern interferometry was applied to measure the deformation of the gel layer. The measured deformation, combined with the properties of the gel layer, served as an input for a finite element solid mechanics computation to determine the stress distribution in the gel layer. The wall shear stress, required to generate the measured deformation of the gel layer, was determined from these computations. A Newtonian buffer solution and a non-Newtonian red blood cell suspension were used as measuring fluids. The deformation of the gel layer was determined for a Newtonian buffer solution to evaluate the method and to obtain the properties of the gel layer. Subsequently, the wall shear stress distribution for the non-Newtonian red blood cell suspension was determined for three different flow rates. The inelastic non-Newtonian Carreau-Yasuda model served as constitutive model for the red blood cell suspension. Using this model, the velocity and wall shear stress distribution were computed by means of a finite element fluid mechanics computation. From the comparison between the numerical and the experimental results, it can be concluded that wall shear stresses, induced by the red blood cell suspension, can be modeled accurately by employing a Carreau-Yasuda model.

Mesh:

Year:  1998        PMID: 10474654     DOI: 10.1016/S0006-355X(99)80010-9

Source DB:  PubMed          Journal:  Biorheology        ISSN: 0006-355X            Impact factor:   1.875


  5 in total

1.  Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images.

Authors:  Byron A Zambrano; Hamidreza Gharahi; ChaeYoung Lim; Farhad A Jaberi; Jongeun Choi; Whal Lee; Seungik Baek
Journal:  Ann Biomed Eng       Date:  2015-10-01       Impact factor: 3.934

2.  Association of vortical structures and hemodynamic parameters for regional thrombus accumulation in abdominal aortic aneurysms.

Authors:  Byron A Zambrano; Hamidreza Gharahi; Chae Young Lim; Whal Lee; Seungik Baek
Journal:  Int J Numer Method Biomed Eng       Date:  2021-12-12       Impact factor: 2.747

3.  A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness.

Authors:  F Helderman; I J Manoch; M Breeuwer; U Kose; O Schouten; M R M van Sambeek; D Poldermans; P T M Pattynama; W Wisselink; A F W van der Steen; R Krams
Journal:  Med Biol Eng Comput       Date:  2008-06-03       Impact factor: 2.602

4.  Influence of right coronary artery motion, flow pulsatility and non-Newtonian rheology on wall shear stress metrics.

Authors:  Pratik Kandangwa; Ryo Torii; Peter D Gatehouse; Spencer J Sherwin; Peter D Weinberg
Journal:  Front Bioeng Biotechnol       Date:  2022-08-09

5.  Fractional Flow Reserve and Instantaneous Wave-Free Ratio Predict Pathological Wall Shear Stress in Coronary Arteries: Implications for Understanding the Pathophysiological Impact of Functionally Significant Coronary Stenoses.

Authors:  Christopher C Y Wong; Ashkan Javadzadegan; Cuneyt Ada; Jerrett K Lau; Ravinay Bhindi; William F Fearon; Leonard Kritharides; Martin K C Ng; Andy S C Yong
Journal:  J Am Heart Assoc       Date:  2022-01-19       Impact factor: 6.106

  5 in total

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