Literature DB >> 10474250

Antisense effects of oligonucleotides complementary to the hairpin of the Leishmania mini-exon RNA.

D Compagno1, J J Toulmé.   

Abstract

We investigated the binding and the translation inhibitory properties of hexadecamers complementary to the mini-exon sequence of the protozoan parasite Leishmania amazonensis. This targeted RNA region folds into a hairpin. Large differences were observed in the antisense properties of the different oligomers although their binding to RNA always requires the disruption of the stem region.

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Year:  1999        PMID： 10474250     DOI： 10.1080/07328319908044827

Source DB:  PubMed          Journal:  Nucleosides Nucleotides        ISSN： 0732-8311


  2 in total

1.  Enhanced activity of antisense phosphorothioate oligos against leishmania amastigotes: augmented uptake of oligo, ribonuclease H activation, and efficient target intervention under altered growth conditions.

Authors:  M Mishra; J M Porter-Kelley; P K Singh; J R Bennett; G Chaudhuri
Journal:  Biochem Pharmacol       Date:  2001-09-01       Impact factor: 5.858

2.  Gene regulation of pteridine reductase 1 in leishmania promastigotes and amastigotes using a full-length antisense construct.

Authors:  F Kheirandish; M Bandehpour; N Davoudi; N Mosaffa; S Dawood; B Kazemi; A Haghighi; A Khamesipour; H Masjedi; M Mohebali; F Mahboudi
Journal:  Iran J Parasitol       Date:  2013-04       Impact factor: 1.012
  2 in total

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