Literature DB >> 10474232

New techniques for the rapid characterization of oligonucleotides by mass spectrometry.

J A McCloskey1, A B Whitehill, J Rozenski, F Qiu, P F Crain.   

Abstract

Recent advances in combined HPLC/electrospray ionization-mass spectrometry provide effective new capabilities for the rapid characterization of oligonucleotides. Accurate mass measurements with errors < 0.3 Da, and determination of base and sugar modification and of nearest neighbor identities, can be routinely carried out on 10-100 component mixtures of RNA or DNA. These procedures are widely applicable in structural and analytical studies involving mixtures of oligonucleotides.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10474232     DOI： 10.1080/07328319908044782

Source DB:  PubMed          Journal:  Nucleosides Nucleotides        ISSN： 0732-8311


  8 in total

Review 1.  Mass spectrometry of RNA: linking the genome to the proteome.

Authors:  Zhaojing Meng; Patrick A Limbach
Journal:  Brief Funct Genomic Proteomic       Date:  2006-02-27

2.  Top-down tandem mass spectrometry of tRNA via ion trap collision-induced dissociation.

Authors:  Teng-Yi Huang; Jian Liu; Scott A McLuckey
Journal:  J Am Soc Mass Spectrom       Date:  2009-12-28       Impact factor: 3.109

3.  Ion trap collision-induced dissociation of multiply deprotonated RNA: c/y-ions versus (a-B)/w-ions.

Authors:  Teng-Yi Huang; Anastasia Kharlamova; Jian Liu; Scott A McLuckey
Journal:  J Am Soc Mass Spectrom       Date:  2008-08-19       Impact factor: 3.109

Review 4.  The multifaceted roles of mass spectrometric analysis in nucleic acids drug discovery and development.

Authors:  Thomas Kenderdine; Dan Fabris
Journal:  Mass Spectrom Rev       Date:  2021-12-23       Impact factor: 9.011

5.  Real-time monitoring of enzymatic DNA hydrolysis by electrospray ionization mass spectrometry.

Authors:  Robert H H van den Heuvel; Sara Gato; Cees Versluis; Pascal Gerbaux; Colin Kleanthous; Albert J R Heck
Journal:  Nucleic Acids Res       Date:  2005-06-13       Impact factor: 16.971

6.  RoboOligo: software for mass spectrometry data to support manual and de novo sequencing of post-transcriptionally modified ribonucleic acids.

Authors:  Paul J Sample; Kirk W Gaston; Juan D Alfonzo; Patrick A Limbach
Journal:  Nucleic Acids Res       Date:  2015-03-27       Impact factor: 16.971

Review 7.  The identification and characterization of non-coding and coding RNAs and their modified nucleosides by mass spectrometry.

Authors:  Kirk W Gaston; Patrick A Limbach
Journal:  RNA Biol       Date:  2014       Impact factor: 4.652

8.  Post-transcriptional modification mapping in the Clostridium acetobutylicum 16S rRNA by mass spectrometry and reverse transcriptase assays.

Authors:  Gert Emmerechts; Sofie Barbé; Piet Herdewijn; Jozef Anné; Jef Rozenski
Journal:  Nucleic Acids Res       Date:  2007-05-03       Impact factor: 16.971
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.