Literature DB >> 10473536

The calcineurin-dynamin 1 complex as a calcium sensor for synaptic vesicle endocytosis.

M M Lai1, J J Hong, A M Ruggiero, P E Burnett, V I Slepnev, P De Camilli, S H Snyder.   

Abstract

Exocytosis of synaptic vesicles is calcium-dependent, with synaptotagmin serving as the calcium sensor. Endocytosis of synaptic vesicles has also been postulated as a calcium-dependent process; however, an endocytic calcium sensor has not been found. We now report a physical association between the calcium-dependent phosphatase calcineurin and dynamin 1, a component of the synaptic endocytic machinery. The calcineurin-dynamin 1 interaction is calcium-dependent, with an EC(50) for calcium in the range of 0.1-0. 4 microM. Disruption of the calcineurin-dynamin 1 interaction inhibits clathrin-mediated endocytosis. Thus, the calcium-dependent formation of the calcineurin-dynamin 1 complex, delivered to the other endocytic coat proteins, provides a calcium-sensing mechanism that facilitates endocytosis.

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Year:  1999        PMID： 10473536     DOI： 10.1074/jbc.274.37.25963

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  49 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-03       Impact factor: 11.205

10.  Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin.

Authors:  Lisa L Gomez; Shuvo Alam; Karen E Smith; Eric Horne; Mark L Dell'Acqua
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167
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