Literature DB >> 10467865

[The determination of clozapine in blood and urine by gas chromatography-mass spectrometry].

A B Melent'ev, I V Kurochkina.   

Abstract

A method for measuring closapine in the blood and urine by gas chromatography-mass spectrometry as a trifluoroacetic derivative is proposed. The threshold level for closapine detection is 25 ng/ml in the blood and 30 ng/ml in the urine. Calibration curves are linear in the range 0.025-5 mcg/ml for the blood and 0.03-50 mcg/ml for the urine. The method can be used in forensic chemical and clinical toxicological analysis.

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Year:  1999        PMID: 10467865

Source DB:  PubMed          Journal:  Sud Med Ekspert        ISSN: 0039-4521


  1 in total

1.  Rapid liquid chromatography/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (norclozapine) in human serum.

Authors:  L V Rao; M L Snyder; G M Vallaro
Journal:  J Clin Lab Anal       Date:  2009       Impact factor: 2.352

  1 in total

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