Literature DB >> 10467579

7-Nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat.

C Hölscher1, L McGlinchey, R Anwyl, M J Rowan.   

Abstract

Nitric oxide (NO) is an intercellular messenger that has been suggested to have a role in learning and memory formation. Previous studies with nonselective NO synthase inhibitors have produced contradictory results in learning experiments. However, these drugs also produced blood pressure changes, as NO is an endothelial-derived relaxing factor. A novel NO synthase inhibitor, 7-nitro indazole (7-NI), as a dose (30 mg/kg i.p.) shown previously to inhibit neuronal NO synthase by 85% without affecting blood pressure, produced amnesic effects both in a water maze and in an 8-arm radial maze. Latency as well as distance was greater in the 7-NI group in the water maze while swim speed was not affected. Latency, working memory (WM), and reference memory (RF) errors were also higher in the 7-NI group in the 8-arm maze. At the end of the second training day, these differences were no longer apparent. However, on the fourth training day, a transfer test in the water maze showed that 7-NI had produced a spatial memory deficit, reducing quadrant bias and the number of annulus crossings. Learning of a visual cue task was not affected. No difference between groups was visible in an open field test. We conclude that neuronal NO synthase activity plays a role in learning and memory formation in the rat.

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Year:  1996        PMID: 10467579     DOI: 10.1101/lm.2.6.267

Source DB:  PubMed          Journal:  Learn Mem        ISSN: 1072-0502            Impact factor:   2.460


  24 in total

1.  Inhibition of the endothelial isoform of nitric oxide synthase impairs long-term memory formation in the chick.

Authors:  N S Rickard; M E Gibbs; K T Ng
Journal:  Learn Mem       Date:  1999 Sep-Oct       Impact factor: 2.460

2.  Blockade of phencyclidine-induced effects by a nitric oxide donor.

Authors:  M Bujas-Bobanovic; D C Bird; H A Robertson; S M Dursun
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

3.  Nitric oxide is involved in the memory facilitation induced by spermidine in rats.

Authors:  Gustavo Petri Guerra; Carlos Fernando Mello; Patricia Dutra Sauzem; Daiane Bolzan Berlese; Ana Flávia Furian; Zuleica Tabarelli; Maribel Antonello Rubin
Journal:  Psychopharmacology (Berl)       Date:  2006-04-07       Impact factor: 4.530

4.  Hemispheric dissociation of the involvement of NOS isoforms in memory for discriminated avoidance in the chick.

Authors:  Nikki S Rickard; Marie E Gibbs
Journal:  Learn Mem       Date:  2003 Sep-Oct       Impact factor: 2.460

5.  Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice.

Authors:  Marika V Doucet; Hester Levine; Kumlesh K Dev; Andrew Harkin
Journal:  Neuropsychopharmacology       Date:  2013-02-27       Impact factor: 7.853

6.  Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats.

Authors:  Lawrence M Carey; Wan-Hung Lee; Tannia Gutierrez; Pushkar M Kulkarni; Ganesh A Thakur; Yvonne Y Lai; Andrea G Hohmann
Journal:  Neuroscience       Date:  2017-03-08       Impact factor: 3.590

7.  The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase.

Authors:  Kristie T Ota; Vicki J Pierre; Jonathan E Ploski; Kaila Queen; Glenn E Schafe
Journal:  Learn Mem       Date:  2008-10-02       Impact factor: 2.460

8.  Effects of restraint stress and nitric oxide synthase inhibition on learning and strategy preference in young adult male rats.

Authors:  Melih Dağdeviren; Yusuf Hakan Doğan; Lütfiye Kanıt
Journal:  Balkan Med J       Date:  2012-12-01       Impact factor: 2.021

9.  A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory.

Authors:  Kathie A Overeem; Kristie T Ota; Melissa S Monsey; Jonathan E Ploski; Glenn E Schafe
Journal:  Front Behav Neurosci       Date:  2010-02-05       Impact factor: 3.558

10.  Effect of fish oils containing different amounts of EPA, DHA, and antioxidants on plasma and brain fatty acids and brain nitric oxide synthase activity in rats.

Authors:  Karin Engström; Ann-Sofie Saldeen; Baichun Yang; Jawahar L Mehta; Tom Saldeen
Journal:  Ups J Med Sci       Date:  2009       Impact factor: 2.384

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