Literature DB >> 10465664

Genetic induction and upregulation of cyclooxygenase (COX) and aromatase (CYP19): an extension of the dietary fat hypothesis of breast cancer.

R E Harris1, F M Robertson, H M Abou-Issa, W B Farrar, R Brueggemeier.   

Abstract

A novel model of mammary carcinogenesis is proposed involving sequential induction and upregulation of cyclooxygenase and aromatase genes by essential fatty acids prominent in the US diet. The basic carcinogenic processes are: (1) constitutive prostaglandin biosynthesis and formation of mutagenic oxygen and nitrogen free radicals responsible for tumor initiation; (2) PGE-2-induced expression of aromatase and constitutive estrogen biosynthesis which sustains mitogenesis and tumor promotion; and (3) PGE-2-induced expression of vascular endothelial growth factor which stimulates angiogenesis and tumor metastasis.

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Year:  1999        PMID： 10465664     DOI： 10.1054/mehy.1998.0009

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  18 in total

1.  Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer.

Authors:  Brian M Kennedy; Randall E Harris
Journal:  Inflammopharmacology       Date:  2018-05-07       Impact factor: 4.473

2.  Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice.

Authors:  Lynda M Evans; Eric C Toline; Renee Desmond; Gene P Siegal; Arig Ibrahim Hashim; Robert W Hardy
Journal:  Clin Exp Metastasis       Date:  2009-03-08       Impact factor: 5.150

3.  Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases.

Authors:  Paulo R C Almeida; Francisco V A Ferreira; Cássio C Santos; Francisco D Rocha-Filho; Raul R R P Feitosa; Esther A A Falcão; Belise K Cavada; Roberto C P Lima-Júnior; Ronaldo A Ribeiro
Journal:  World J Gastroenterol       Date:  2012-02-28       Impact factor: 5.742

Review 4.  Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.

Authors:  Thea D Tlsty; Yongping G Crawford; Charles R Holst; Colleen A Fordyce; Jianmin Zhang; Kimberly McDermott; Krystyna Kozakiewicz; Mona L Gauthier
Journal:  J Mammary Gland Biol Neoplasia       Date:  2004-07       Impact factor: 2.673

Review 5.  Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis.

Authors:  O C Trifan; T Hla
Journal:  J Cell Mol Med       Date:  2003 Jul-Sep       Impact factor: 5.310

6.  The conversion of rapid TCCD nongenomic signals to persistent inflammatory effects via select protein kinases in MCF10A cells.

Authors:  Bin Dong; Fumio Matsumura
Journal:  Mol Endocrinol       Date:  2009-01-15

7.  Aromatase and COX in breast cancer: enzyme inhibitors and beyond.

Authors:  Robert W Brueggemeier; Bin Su; Yasuro Sugimoto; Edgar S Díaz-Cruz; Danyetta D Davis
Journal:  J Steroid Biochem Mol Biol       Date:  2007-05-25       Impact factor: 4.292

Review 8.  Cyclooxygenase-2 and the inflammogenesis of breast cancer.

Authors:  Randall E Harris; Bruce C Casto; Zachary M Harris
Journal:  World J Clin Oncol       Date:  2014-10-10

Review 9.  COX-2 inhibitors for the prevention of breast cancer.

Authors:  Louise R Howe; Andrew J Dannenberg
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-01       Impact factor: 2.673

10.  Analysis of Cox-2 and thromboxane synthase expression in pituitary adenomas and carcinomas.

Authors:  Onder Onguru; Bernd W Scheithauer; Kalman Kovacs; Sergio Vidal; Long Jin; Shuya Zhang; Katharina H Ruebel; Ricardo V Lloyd
Journal:  Endocr Pathol       Date:  2004       Impact factor: 4.056
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