| Literature DB >> 10465561 |
W C Xu1, Q Zhou, C L Ashendel, C T Chang, C J Chang.
Abstract
A series of beta-substituted polythiophene derivatives was synthesized through palladium-catalyzed coupling reaction. Their structure-protein kinase C (PKC) inhibitory activity relationship was studied. The carboxaldehyde and hydroxymethyl derivatives of alpha-terthiophene were potent PKC inhibitors (IC50 = 10(-7) M).Entities:
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Year: 1999 PMID： 10465561 DOI： 10.1016/s0960-894x(99)00375-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823