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Literature DB >> 10465560

Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs).

D A Johnson¹, C G Sowell, C L Johnson, M T Livesay, D S Keegan, M J Rhodes, J T Ulrich, J R Ward, J L Cantrell, V G Brookshire.

Abstract

A novel series of acylated omega-aminoalkyl 2-amino-2-deoxy-4-phosphono-beta-D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toxoid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells.

Entities: Chemical Disease Species

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Year: 1999 PMID： 10465560 DOI： 10.1016/s0960-894x(99)00374-1

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

22 in total

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4. PppA, a surface-exposed protein of Streptococcus pneumoniae, elicits cross-reactive antibodies that reduce colonization in a murine intranasal immunization and challenge model.

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5. Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge.

Authors: Christopher W Cluff; Jory R Baldridge; Axel G Stöver; Jay T Evans; David A Johnson; Michael J Lacy; Valerie G Clawson; Vonnie M Yorgensen; Craig L Johnson; Mark T Livesay; Robert M Hershberg; David H Persing
Journal: Infect Immun Date: 2005-05 Impact factor: 3.441

Synthesis and biological evaluation of a new class of vaccine adjuvants: aminoalkyl glucosaminide 4-phosphates (AGPs).

1. Adjuvant formulations possess differing efficacy in the potentiation of antibody and cell mediated responses to a human malaria vaccine under selective immune genes knockout environment.

Review 2. Progress in the synthesis and biological evaluation of lipid A and its derivatives.

3. Dissociation of TRIF bias and adjuvanticity.

4. PppA, a surface-exposed protein of Streptococcus pneumoniae, elicits cross-reactive antibodies that reduce colonization in a murine intranasal immunization and challenge model.

5. Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge.

6. Characterization of TRIF selectivity in the AGP class of lipid A mimetics: role of secondary lipid chains.

7. A purified capsular polysaccharide markedly inhibits inflammatory response during endotoxic shock.

Review 8. Modulating LPS signal transduction at the LPS receptor complex with synthetic Lipid A analogues.

Review 9. Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant.

10. Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia.