Literature DB >> 10465558

Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists.

S C Bergmeier1, D J Lapinsky, R B Free, D B McKay.   

Abstract

We have prepared ring E analogs of the diterpenoid alkaloid methyllycaconitine. These compounds have been assayed for nicotinic activity and were found to act as functional antagonists on adrenal nicotinic receptors.

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Year:  1999        PMID： 10465558     DOI： 10.1016/s0960-894x(99)00378-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.

Authors:  Brandon J Henderson; Ryan E Pavlovicz; Jerad D Allen; Tatiana F González-Cestari; Crina M Orac; Andrew B Bonnell; Michael X Zhu; R Thomas Boyd; Chenglong Li; Stephen C Bergmeier; Dennis B McKay
Journal:  J Pharmacol Exp Ther       Date:  2010-06-15       Impact factor: 4.030

2.  3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors.

Authors:  Brandon J Henderson; Crina M Orac; Iwona Maciagiewicz; Stephen C Bergmeier; Dennis B McKay
Journal:  Bioorg Med Chem Lett       Date:  2011-11-20       Impact factor: 2.823

3.  Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery.

Authors:  Tatiana F González-Cestari; Brandon J Henderson; Ryan E Pavlovicz; Susan B McKay; Raed A El-Hajj; Aravinda B Pulipaka; Crina M Orac; Damon D Reed; R Thomas Boyd; Michael X Zhu; Chenglong Li; Stephen C Bergmeier; Dennis B McKay
Journal:  J Pharmacol Exp Ther       Date:  2008-11-04       Impact factor: 4.030

4.  Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors.

Authors:  Brandon J Henderson; Tatiana F González-Cestari; Bitna Yi; Ryan E Pavlovicz; R Thomas Boyd; Chenglong Li; Stephen C Bergmeier; Dennis B McKay
Journal:  ACS Chem Neurosci       Date:  2012-05-25       Impact factor: 4.418

5.  Diastereoselective Synthesis of a Highly Substituted cis-Decahydroquinoline via a Knoevenagel Condensation.

Authors:  Junfeng Huang; Stephen C Bergmeier
Journal:  Tetrahedron       Date:  2008-06-30       Impact factor: 2.457

6.  Screening a Natural Product-Inspired Library for Anti-Phytophthora Activities.

Authors:  Scott A Lawrence; Hannah F Robinson; Daniel P Furkert; Margaret A Brimble; Monica L Gerth
Journal:  Molecules       Date:  2021-03-24       Impact factor: 4.411
  6 in total

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