| Literature DB >> 10465550 |
T D Aicher1, R E Damon, J Koletar, C C Vinluan, L J Brand, J Gao, S S Shetty, E L Kaplan, W R Mann.
Abstract
Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse after a single oral dose of 100 micromol/kg. However, the mechanism of the blood glucose lowering effect is likely unrelated to PDK inhibition.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10465550 DOI： 10.1016/s0960-894x(99)00380-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823