| Literature DB >> 10465547 |
Y Leblanc1, P Roy, S Boyce, C Brideau, C C Chan, S Charleson, R Gordon, E Grimm, J Guay, S Léger, C S Li, D Riendeau, D Visco, Z Wang, J Webb, L J Xu, P Prasit.
Abstract
Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4-methanesulfonylphenyl)-2(5H)-furanon e), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10465547 DOI： 10.1016/s0960-894x(99)00365-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823