Literature DB >> 10465544

Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).

T Fryatt1, D T Goroski, Z D Nilson, C J Moody, H D Beall.   

Abstract

The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10465544     DOI： 10.1016/s0960-894x(99)00369-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Hybrids of 1,4-Quinone with Quinoline Derivatives: Synthesis, Biological Activity, and Molecular Docking with DT-Diaphorase (NQO1).

Authors:  Monika Kadela-Tomanek; Maria Jastrzębska; Elwira Chrobak; Ewa Bębenek; Małgorzata Latocha
Journal:  Molecules       Date:  2022-09-21       Impact factor: 4.927

2.  Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis.

Authors:  Timothy J Donohoe; Christopher R Jones; Anne F Kornahrens; Luiz C A Barbosa; Louise J Walport; Matthew R Tatton; Michael O'Hagan; Akshat H Rathi; David B Baker
Journal:  J Org Chem       Date:  2013-12-12       Impact factor: 4.354
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.