| Literature DB >> 10465540 |
K L Yu1, E Ruediger, G Luo, C Cianci, S Danetz, L Tiley, A K Trehan, I Monkovic, B Pearce, A Martel, M Krystal, N A Meanwell.
Abstract
A novel series of quinolizidine salicylamides was synthesized as specific inhibitors of the H1 subtype of influenza A viruses. These inhibitors inhibit the pH-induced fusion process, thereby blocking viral entry into host cells. Compound 16 was the most active inhibitor in this series with an EC50 of 0.25 microg/mL in plaque reduction assay. The synthesis and the SAR of these compounds are discussed.Entities:
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Year: 1999 PMID： 10465540 DOI： 10.1016/s0960-894x(99)00361-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823