| Literature DB >> 10465419 |
K Kanoh1, S Kohno, J Katada, J Takahashi, I Uno, Y Hayashi.
Abstract
X-ray crystallographic analysis was performed and several phenylahistin derivatives were synthesized to elucidate the structural components necessary for the anti-microtubule activity of phenylahistin. We primarily focused on the unique isoprenylated dehydrohistidine structure. Our results showed that a uniplanar pseudo-three-ring structure formed by the hydrogen bonding of diketopiperazine and imidazole rings is important for the anti-microtubule activity of phenylahistin.Entities:
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Year: 1999 PMID： 10465419 DOI： 10.1016/s0968-0896(99)00059-0
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641