Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Escherichia coli NadR regulator is endowed with nicotinamide mononucleotide adenylyltransferase activity.

Literature DB >> 10464228

The Escherichia coli NadR regulator is endowed with nicotinamide mononucleotide adenylyltransferase activity.

N Raffaelli¹, T Lorenzi, P L Mariani, M Emanuelli, A Amici, S Ruggieri, G Magni.

Abstract

The first identification and characterization of a catalytic activity associated with NadR protein is reported. A computer-aided search for sequence similarity revealed the presence in NadR of a 29-residue region highly conserved among known nicotinamide mononucleotide adenylyltransferases. The Escherichia coli nadR gene was cloned into a T7-based vector and overexpressed. In addition to functionally specific DNA binding properties, the homogeneous recombinant protein catalyzes NAD synthesis from nicotinamide mononucleotide and ATP.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10464228 PMCID： PMC94063

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

19 in total

1. Synechocystis sp. slr0787 protein is a novel bifunctional enzyme endowed with both nicotinamide mononucleotide adenylyltransferase and 'Nudix' hydrolase activities.

Authors: N Raffaelli; T Lorenzi; A Amici; M Emanuelli; S Ruggieri; G Magni
Journal: FEBS Lett Date: 1999-02-12 Impact factor: 4.124

2. Regulation of proline utilization in Salmonella typhimurium: a membrane-associated dehydrogenase binds DNA in vitro.

Authors: P Ostrovsky de Spicer; K O'Brien; S Maloy
Journal: J Bacteriol Date: 1991-01 Impact factor: 3.490

3. Nicotinamide mononucleotide adenylyltransferase. Molecular and enzymatic properties of the homogeneous enzyme from baker's yeast.

Authors: P Natalini; S Ruggieri; N Raffaelli; G Magni
Journal: Biochemistry Date: 1986-06-17 Impact factor: 3.162

4. Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon.

Authors: J W Foster; Y K Park; T Penfound; T Fenger; M P Spector
Journal: J Bacteriol Date: 1990-08 Impact factor: 3.490

5. Discontinuous DNA replication in vitro. I. Two distinct size classes of intermediates.

Authors: B M Olivera; F Bonhoeffer
Journal: Nat New Biol Date: 1972-12-20

6. The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast.

Authors: W Dahmen; B Webb; J Preiss
Journal: Arch Biochem Biophys Date: 1967-05 Impact factor: 4.013

7. Recognition of a gene involved in the regulation of nicotinamide adenine dinucleotide biosynthesis.

Authors: G J Tritz; J L Chandler
Journal: J Bacteriol Date: 1973-04 Impact factor: 3.490

8. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.

Authors: F W Studier; B A Moffatt
Journal: J Mol Biol Date: 1986-05-05 Impact factor: 5.469

9. Identification of a repressor gene involved in the regulation of NAD de novo biosynthesis in Salmonella typhimurium.

Authors: N Zhu; B M Olivera; J R Roth
Journal: J Bacteriol Date: 1988-01 Impact factor: 3.490

10. Regulation of NAD biosynthesis in Salmonella typhimurium: expression of nad-lac gene fusions and identification of a nad regulatory locus.

Authors: E A Holley; M P Spector; J W Foster
Journal: J Gen Microbiol Date: 1985-10

36 in total

1. Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene.

Authors: R A Mehl; C Kinsland; T P Begley
Journal: J Bacteriol Date: 2000-08 Impact factor: 3.490

2. Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis.

Authors: Oleg V Kurnasov; Boris M Polanuyer; Shubha Ananta; Roman Sloutsky; Annie Tam; Svetlana Y Gerdes; Andrei L Osterman
Journal: J Bacteriol Date: 2002-12 Impact factor: 3.490

3. YrxA is the transcriptional regulator that represses de novo NAD biosynthesis in Bacillus subtilis.

Authors: Paola Rossolillo; Ilaria Marinoni; Elisa Galli; Anna Colosimo; Alessandra M Albertini
Journal: J Bacteriol Date: 2005-10 Impact factor: 3.490

4. Coupling of NAD+ biosynthesis and nicotinamide ribosyl transport: characterization of NadR ribonucleotide kinase mutants of Haemophilus influenzae.

Authors: Melisa Merdanovic; Elizabeta Sauer; Joachim Reidl
Journal: J Bacteriol Date: 2005-07 Impact factor: 3.490