Literature DB >> 10464096

Dual function of the selenoprotein PHGPx during sperm maturation.

F Ursini1, S Heim, M Kiess, M Maiorino, A Roveri, J Wissing, L Flohé.   

Abstract

The selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) changes its physical characteristics and biological functions during sperm maturation. PHGPx exists as a soluble peroxidase in spermatids but persists in mature spermatozoa as an enzymatically inactive, oxidatively cross-linked, insoluble protein. In the midpiece of mature spermatozoa, PHGPx protein represents at least 50 percent of the capsule material that embeds the helix of mitochondria. The role of PHGPx as a structural protein may explain the mechanical instability of the mitochondrial midpiece that is observed in selenium deficiency.

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Year:  1999        PMID： 10464096     DOI： 10.1126/science.285.5432.1393

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  144 in total

1.  A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs.

Authors:  P R Copeland; J E Fletcher; B A Carlson; D L Hatfield; D M Driscoll
Journal:  EMBO J       Date:  2000-01-17       Impact factor: 11.598

2.  In silico identification of novel selenoproteins in the Drosophila melanogaster genome.

Authors:  S Castellano; N Morozova; M Morey; M J Berry; F Serras; M Corominas; R Guigó
Journal:  EMBO Rep       Date:  2001-08       Impact factor: 8.807

3.  Immunolocalization of a plant glutathione peroxidase-like protein.

Authors:  Stéphane Herbette; Nicole Brunel; Gérard Prensier; Jean-Louis Julien; Joël R Drevet; Patricia Roeckel-Drevet
Journal:  Planta       Date:  2004-05-26       Impact factor: 4.116

4.  Efficiency of mammalian selenocysteine incorporation.

Authors:  Anupama Mehta; Cheryl M Rebsch; Scott A Kinzy; Julia E Fletcher; Paul R Copeland
Journal:  J Biol Chem       Date:  2004-06-30       Impact factor: 5.157

5.  On the road to selenocysteine.

Authors:  Alan M Diamond
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-07       Impact factor: 11.205

6.  Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis.

Authors:  Sun Hee Yim; Yoo-Jin Kim; Sue Young Oh; Junichi Fujii; Yan Zhang; Vadim N Gladyshev; Sue Goo Rhee
Journal:  J Biol Chem       Date:  2011-08-11       Impact factor: 5.157

7.  Hydrogen peroxide produced by superoxide dismutase SOD-2 activates sperm in Caenorhabditis elegans.

Authors:  Taro Sakamoto; Hirotaka Imai
Journal:  J Biol Chem       Date:  2017-07-19       Impact factor: 5.157

8.  Selenium requirements are higher for glutathione peroxidase-1 mRNA than gpx1 activity in rat testis.

Authors:  Sonja C Schriever; Kimberly M Barnes; Jacqueline K Evenson; Anna M Raines; Roger A Sunde
Journal:  Exp Biol Med (Maywood)       Date:  2009-02-20

9.  The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.

Authors:  M Conrad; S G Moreno; F Sinowatz; F Ursini; S Kölle; A Roveri; M Brielmeier; W Wurst; M Maiorino; G W Bornkamm
Journal:  Mol Cell Biol       Date:  2005-09       Impact factor: 4.272

Review 10.  Selenium and cancer: biomarkers of selenium status and molecular action of selenium supplements.

Authors:  Jolanta Gromadzińska; Edyta Reszka; Katharina Bruzelius; Wojciech Wasowicz; Björn Akesson
Journal:  Eur J Nutr       Date:  2008-05       Impact factor: 5.614
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