Literature DB >> 10463773

The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo.

M Okamoto-Inoue1, S Kamada, G Kimura, S Taniguchi.   

Abstract

A normal rat fibroblast 3Y1 cell line expresses smooth muscle a actin and the expression of alpha actin is suppressed in the transformant (SR-3Y1-2) induced by a Raus sarcoma virus. Gene transfer with smooth muscle alpha actin into the SR-3Y1-2 cell line reduced growth and invasiveness in vitro, as well as tumor growth and experimental lung metastasis depending on the expression of the alpha actin. These results indicated that smooth muscle alpha actin is involved in the regulation of cell growth as well as cell motility and thus leads to the suppression of malignant phenotypes in transformed cells.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10463773     DOI： 10.1016/s0304-3835(99)00150-0

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

1.  Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression.

Authors:  Helga Lind Nielsen; Thorarinn Gudjonsson; René Villadsen; Lone Rønnov-Jessen; Ole William Petersen
Journal:  In Vitro Cell Dev Biol Anim       Date:  2003 Jul-Aug       Impact factor: 2.416

Review 2.  Putting tumours in context.

Authors:  M J Bissell; D Radisky
Journal:  Nat Rev Cancer       Date:  2001-10       Impact factor: 60.716

3.  Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis.

Authors:  Tiegang Liu; Rod R Warburton; Oscar E Guevara; Nicholas S Hill; Barry L Fanburg; Matthias Gaestel; Usamah S Kayyali
Journal:  Am J Respir Cell Mol Biol       Date:  2007-06-28       Impact factor: 6.914

4.  Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition.

Authors:  Thorarinn Gudjonsson; Lone Rønnov-Jessen; René Villadsen; Fritz Rank; Mina J Bissell; Ole William Petersen
Journal:  J Cell Sci       Date:  2002-01-01       Impact factor: 5.285

5.  Myoepithelial cells: good fences make good neighbors.

Authors:  Melissa C Adriance; Jamie L Inman; Ole W Petersen; Mina J Bissell
Journal:  Breast Cancer Res       Date:  2005-07-12       Impact factor: 6.466

Review 6.  The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion.

Authors:  O W Petersen; H Lind Nielsen; T Gudjonsson; R Villadsen; L Rønnov-Jessen; M J Bissell
Journal:  Breast Cancer Res       Date:  2001-06-12       Impact factor: 6.466

7.  Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity.

Authors:  Lihua Chen; Allison DeWispelaere; Frank Dastvan; William R A Osborne; Christine Blechner; Sabine Windhorst; Guenter Daum
Journal:  PLoS One       Date:  2016-05-13       Impact factor: 3.240

8.  Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness.

Authors:  M Moazzem Hossain; Xin Wang; Raymond C Bergan; J-P Jin
Journal:  FEBS Open Bio       Date:  2014-06-24       Impact factor: 2.693

Review 9.  Role of myoepithelial cells in breast tumor progression.

Authors:  Puspa Raj Pandey; Jamila Saidou; Kounosuke Watabe
Journal:  Front Biosci (Landmark Ed)       Date:  2010-01-01
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.