BACKGROUND: Marmosets in captivity are highly susceptible to wasting marmoset syndrome (WMS), the aetiology of which is still not fully determined. METHODS: The level of IgA-gliadin antibodies (IgA-AGA), of IgA-containing circulating immune complexes (IgA-CIC), and the degree of glomerular IgA deposits were compared between marmosets suffering from WMS and animals not affected by the disorder. RESULTS: Both IgA-AGA and IgA-CIC were demonstrable in all groups of monkeys investigated. IgA-AGA and IgA-CIC were significantly higher in monkeys with WMS than in non-affected animals. There was a significant correlation between the glomerular IgA-deposition and titre of IgA-AGA. The group of marmosets strongly positive for glomerular IgA deposits comprised significantly more animals suffering from WMS than the group without deposits. In the diet of the animals a considerable amount of gliadin-like cereal proteins was assayed. CONCLUSIONS: There are several parallels between the human disorders (coeliac disease and IgA-nephropathy/Berger's disease) and the changes observed in WMS. It should be further investigated if WMS in marmosets is a suitable animal model for both human diseases.
BACKGROUND:Marmosets in captivity are highly susceptible to wasting marmoset syndrome (WMS), the aetiology of which is still not fully determined. METHODS: The level of IgA-gliadin antibodies (IgA-AGA), of IgA-containing circulating immune complexes (IgA-CIC), and the degree of glomerular IgA deposits were compared between marmosets suffering from WMS and animals not affected by the disorder. RESULTS: Both IgA-AGA and IgA-CIC were demonstrable in all groups of monkeys investigated. IgA-AGA and IgA-CIC were significantly higher in monkeys with WMS than in non-affected animals. There was a significant correlation between the glomerular IgA-deposition and titre of IgA-AGA. The group of marmosets strongly positive for glomerular IgA deposits comprised significantly more animals suffering from WMS than the group without deposits. In the diet of the animals a considerable amount of gliadin-like cereal proteins was assayed. CONCLUSIONS: There are several parallels between the human disorders (coeliac disease and IgA-nephropathy/Berger's disease) and the changes observed in WMS. It should be further investigated if WMS in marmosets is a suitable animal model for both human diseases.
Authors: V G Sasseville; K G Mansfield; J L Mankowski; C Tremblay; K A Terio; K Mätz-Rensing; E Gruber-Dujardin; M A Delaney; L D Schmidt; D Liu; J E Markovits; M Owston; C Harbison; S Shanmukhappa; A D Miller; S Kaliyaperumal; B T Assaf; L Kattenhorn; S Cummings Macri; H A Simmons; A Baldessari; P Sharma; C Courtney; A Bradley; J M Cline; J F Reindel; D L Hutto; R J Montali; L J Lowenstine Journal: Vet Pathol Date: 2012-11 Impact factor: 2.221
Authors: Darryl Falzarano; Emmie de Wit; Friederike Feldmann; Angela L Rasmussen; Atsushi Okumura; Xinxia Peng; Matthew J Thomas; Neeltje van Doremalen; Elaine Haddock; Lee Nagy; Rachel LaCasse; Tingting Liu; Jiang Zhu; Jason S McLellan; Dana P Scott; Michael G Katze; Heinz Feldmann; Vincent J Munster Journal: PLoS Pathog Date: 2014-08-21 Impact factor: 6.823
Authors: Alexander Sheh; Stephen C Artim; Monika A Burns; Jose Arturo Molina-Mora; Mary Anne Lee; JoAnn Dzink-Fox; Sureshkumar Muthupalani; James G Fox Journal: Sci Rep Date: 2022-03-15 Impact factor: 4.379
Authors: Victoria K Baxter; Gillian C Shaw; Nathaniel P Sotuyo; Cathy S Carlson; Erik J Olson; M Christine Zink; Joseph L Mankowski; Robert J Adams; Eric K Hutchinson; Kelly A Metcalf Pate Journal: PLoS One Date: 2013-12-06 Impact factor: 3.240
Authors: Barbora Knoppova; Colin Reily; Nicolas Maillard; Dana V Rizk; Zina Moldoveanu; Jiri Mestecky; Milan Raska; Matthew B Renfrow; Bruce A Julian; Jan Novak Journal: Front Immunol Date: 2016-04-12 Impact factor: 7.561