Literature DB >> 10461216

Calcium channel activation stabilizes a neuronal calcium channel mRNA.

S Schorge1, S Gupta, Z Lin, M W McEnery, D Lipscombe.   

Abstract

We have identified a calcium-dependent pathway in neurons that regulates expression levels of the alpha1B subunit and N channel current. When neurons are depolarized and voltage-gated calcium channels activated, the half-life of cellular N channel alpha1B mRNA is prolonged. This stabilizing effect of depolarization is mediated through the 3' untranslated region of a long form of the alpha1B mRNA and may represent a form of modulation of N-channel levels that does not require changes in gene transcription. Increases in N channel expression would affect several key neuronal functions controlled by calcium, including transmitter release and neurite outgrowth.

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Year:  1999        PMID： 10461216     DOI： 10.1038/12153

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  11 in total

1.  Alternative splicing in the cytoplasmic II-III loop of the N-type Ca channel alpha 1B subunit: functional differences are beta subunit-specific.

Authors:  J Q Pan; D Lipscombe
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

2.  The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression.

Authors:  Fraser J Moss; Patricia Viard; Anthony Davies; Federica Bertaso; Karen M Page; Alex Graham; Carles Cantí; Mary Plumpton; Christopher Plumpton; Jeffrey J Clare; Annette C Dolphin
Journal:  EMBO J       Date:  2002-04-02       Impact factor: 11.598

Review 3.  Functional diversity in neuronal voltage-gated calcium channels by alternative splicing of Ca(v)alpha1.

Authors:  Diane Lipscombe; Jennifer Qian Pan; Annette C Gray
Journal:  Mol Neurobiol       Date:  2002-08       Impact factor: 5.590

4.  Increased expression of alpha 1A Ca2+ channel currents arising from expanded trinucleotide repeats in spinocerebellar ataxia type 6.

Authors:  E S Piedras-Renteria; K Watase; N Harata; O Zhuchenko; H Y Zoghbi; C C Lee; R W Tsien
Journal:  J Neurosci       Date:  2001-12-01       Impact factor: 6.167

5.  Physiological patterns of electrical stimulation can induce neuronal gene expression by activating N-type calcium channels.

Authors:  T A Brosenitsch; D M Katz
Journal:  J Neurosci       Date:  2001-04-15       Impact factor: 6.167

6.  The untranslated region of (mu)-opioid receptor mRNA contributes to reduced opioid sensitivity in CXBK mice.

Authors:  K Ikeda; T Kobayashi; T Ichikawa; T Kumanishi; H Niki; R Yano
Journal:  J Neurosci       Date:  2001-02-15       Impact factor: 6.167

7.  Molecular basis of R-type calcium channels in central amygdala neurons of the mouse.

Authors:  Seung-Chan Lee; Sukwoo Choi; Taehoon Lee; Hyung-Lae Kim; Hemin Chin; Hee-Sup Shin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

8.  Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein.

Authors:  A Ashleigh Long; Eunju Kim; Hung-Tat Leung; Elvin Woodruff; Lingling An; R W Doerge; William L Pak; Kendal Broadie
Journal:  J Neurosci       Date:  2008-04-02       Impact factor: 6.167

9.  The stargazin-related protein gamma 7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including CaV2.2.

Authors:  Laurent Ferron; Anthony Davies; Karen M Page; David J Cox; Jerôme Leroy; Dominic Waithe; Adrian J Butcher; Priya Sellaturay; Steven Bolsover; Wendy S Pratt; Fraser J Moss; Annette C Dolphin
Journal:  J Neurosci       Date:  2008-10-15       Impact factor: 6.167

10.  Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons.

Authors:  Mohamed A Motagally; Mark K Lukewich; Susan P Chisholm; Shadia Neshat; Alan E Lomax
Journal:  J Physiol       Date:  2009-04-29       Impact factor: 5.182
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