Literature DB >> 10459817

Effects of voriconazole on Candida glabrata in vitro.

A Koul1, J Vitullo, G Reyes, M Ghannoum.   

Abstract

The effects of voriconazole on the growth, morphology and lipids of Candida glabrata were studied. MIC data showed that voriconazole was up to 32- to 64-fold more active than fluconazole in its ability to inhibit various C. glabrata strains. Voriconazole inhibited the growth of C. glabrata in a dose-dependent fashion. Electron microscope examination showed that voriconazole treatment affected the external and internal morphology of C. glabrata. Treatment of C. glabrata with voriconazole inhibited ergosterol synthesis and led to accumulation of methylated sterols. In contrast, no significant difference in phospholipid composition was observed between treated and untreated cells.

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Year:  1999        PMID： 10459817     DOI： 10.1093/jac/44.1.109

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  8 in total

1.  Serum voriconazole levels following administration via percutaneous jejunostomy tube.

Authors:  Valérie Martinez; Jean-Luc Le Guillou; Christian Lamer; Melissande Le Jouan; Michel Tod; Françoise Dromer
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

2.  Innate inflammatory response and immunopharmacologic activity of micafungin, caspofungin, and voriconazole against wild-type and FKS mutant Candida glabrata isolates.

Authors:  Nicholas D Beyda; Guangling Liao; Bradley T Endres; Russell E Lewis; Kevin W Garey
Journal:  Antimicrob Agents Chemother       Date:  2015-06-22       Impact factor: 5.191

3.  In vitro and in vivo effects of 14alpha-demethylase (ERG11) depletion in Candida glabrata.

Authors:  H Nakayama; N Nakayama; M Arisawa; Y Aoki
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

4.  Posaconazole is a potent inhibitor of sterol 14alpha-demethylation in yeasts and molds.

Authors:  Hanan K Munayyer; Paul A Mann; Andrew S Chau; Taisa Yarosh-Tomaine; Jonathan R Greene; Roberta S Hare; Larry Heimark; Robert E Palermo; David Loebenberg; Paul M McNicholas
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

5.  Comparative Study of the Effects of Fluconazole and Voriconazole on Candida glabrata, Candida parapsilosis and Candida rugosa Biofilms.

Authors:  Priya Madhavan; Farida Jamal; Chong Pei Pei; Fauziah Othman; Arunkumar Karunanidhi; Kee Peng Ng
Journal:  Mycopathologia       Date:  2018-01-29       Impact factor: 2.574

Review 6.  In vitro antifungal activities of voriconazole and reference agents as determined by NCCLS methods: review of the literature.

Authors:  A Espinel-Ingroff; K Boyle; D J Sheehan
Journal:  Mycopathologia       Date:  2001       Impact factor: 3.785

7.  Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis.

Authors:  Kelly Ishida; Juliany Cola Fernandes Rodrigues; Simon Cammerer; Julio A Urbina; Ian Gilbert; Wanderley de Souza; Sonia Rozental
Journal:  Ann Clin Microbiol Antimicrob       Date:  2011-01-21       Impact factor: 3.944

8.  Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms.

Authors:  Kelly Ishida; Juliany Cola Fernandes Rodrigues; Marcos Dornelas Ribeiro; Taíssa Vieira Machado Vila; Wanderley de Souza; Julio A Urbina; Celso Vataru Nakamura; Sonia Rozental
Journal:  BMC Microbiol       Date:  2009-04-20       Impact factor: 3.605
  8 in total

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