PURPOSE: Blast expression of CD56 is frequent in patients with t(8;21)(q22;q22) acute myeloid leukemia and is associated with an inferior outcome. The expression of CD56 has rarely been reported in acute promyelocytic leukemia (APL) and has not been clinically characterized. Therefore, we examined the prognostic significance of CD56 expression in APL. PATIENTS AND METHODS: We identified all reported cases of CD56+ APL in the medical literature and collected clinical, biologic, and therapeutic details. RESULTS: Data were obtained for 12 patients with CD56+ APL (> 20% blast expression of CD56), including four cases from a single institution with a total of 42 APL patients. All of the CD56+ APL patients had documented cytogenetic presence of t(15;17), and of the nine reported isotypes, eight (89%) were S-isoform. Only six CD56+ patients (50%) attained complete remission (CR); the other six individuals died within 35 days of presentation. Of the six patients who attained a CR, three (50%) relapsed at 111, 121, and 155 weeks, whereas three remained in continuous CR at 19, 90, and 109 weeks. Comparison of the control CD56- to CD56+ APL patients demonstrated that the latter group had a significantly lower fibrinogen level (P = .007), and among patients for whom data were available, there was a higher frequency of the S-isoform (P = .006). Additionally, the CR rate (50% v 84%, P = .025) and overall median survival (5 v 232 weeks; P = .019) were significantly inferior for CD56+ APL patients. CONCLUSION: CD56+ acute promyelocytic leukemia is infrequent, seems to occur more frequently with the S-isoform subtype, and may be associated with a lower CR rate and inferior overall survival.
PURPOSE: Blast expression of CD56 is frequent in patients with t(8;21)(q22;q22) acute myeloid leukemia and is associated with an inferior outcome. The expression of CD56 has rarely been reported in acute promyelocytic leukemia (APL) and has not been clinically characterized. Therefore, we examined the prognostic significance of CD56 expression in APL. PATIENTS AND METHODS: We identified all reported cases of CD56+ APL in the medical literature and collected clinical, biologic, and therapeutic details. RESULTS: Data were obtained for 12 patients with CD56+ APL (> 20% blast expression of CD56), including four cases from a single institution with a total of 42 APLpatients. All of the CD56+ APLpatients had documented cytogenetic presence of t(15;17), and of the nine reported isotypes, eight (89%) were S-isoform. Only six CD56+ patients (50%) attained complete remission (CR); the other six individuals died within 35 days of presentation. Of the six patients who attained a CR, three (50%) relapsed at 111, 121, and 155 weeks, whereas three remained in continuous CR at 19, 90, and 109 weeks. Comparison of the control CD56- to CD56+ APLpatients demonstrated that the latter group had a significantly lower fibrinogen level (P = .007), and among patients for whom data were available, there was a higher frequency of the S-isoform (P = .006). Additionally, the CR rate (50% v 84%, P = .025) and overall median survival (5 v 232 weeks; P = .019) were significantly inferior for CD56+ APLpatients. CONCLUSION:CD56+ acute promyelocytic leukemia is infrequent, seems to occur more frequently with the S-isoform subtype, and may be associated with a lower CR rate and inferior overall survival.
Authors: Muhamed Baljevic; Bogdan Dumitriu; Ju-Whei Lee; Elisabeth M Paietta; Peter H Wiernik; Janis Racevskis; Christina Chen; Eytan M Stein; Robert E Gallagher; Jacob M Rowe; Frederick R Appelbaum; Bayard L Powell; Richard A Larson; Steven E Coutré; Jeffrey Lancet; Mark R Litzow; Selina M Luger; Neal S Young; Martin S Tallman Journal: Acta Haematol Date: 2016-09-16 Impact factor: 2.195
Authors: Chalid Assaf; Sylke Gellrich; Sean Whittaker; Alistair Robson; Lorenzo Cerroni; Cesare Massone; Helmut Kerl; Christian Rose; Andreas Chott; Sergio Chimenti; Christian Hallermann; Tony Petrella; Janine Wechsler; Martine Bagot; Michael Hummel; Katrin Bullani-Kerl; Marcel W Bekkenk; Werner Kempf; Chris J L M Meijer; Rein Willemze; Wolfram Sterry Journal: J Clin Pathol Date: 2006-10-03 Impact factor: 3.411
Authors: Marvin M van Luijn; Theresia M Westers; Martine E D Chamuleau; S Marieke van Ham; Gert J Ossenkoppele; Arjan A van de Loosdrecht Journal: Am J Pathol Date: 2011-09-09 Impact factor: 4.307