Literature DB >> 10456962

Experimental transmission of Neisseria gonorrhoeae from pregnant rat to fetus.

S Nowicki1, R Selvarangan, G Anderson.   

Abstract

Sprague-Dawley rats were infected on day 20 of pregnancy by intraperitoneal inoculation with Neisseria gonorrhoeae. Disseminated gonococcal infection (DGI) and pelvic inflammatory disease (PID) strains in the presence of C1q but not in the presence of bovine serum albumin (BSA) were able to spread from the pregnant rat to the fetus and resulted in fetal mortality. Transmission of DGI and PID strains that are serum resistant (ser(r)) and sac-4 positive but not of a local infection strain that is ser(s) and sac-4 negative was facilitated by the C1q-dependent mechanism. This study provides the first experimental model that may mimic the transmission of gonococcal infection from mother to the fetus during pregnancy.

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Year:  1999        PMID： 10456962      PMCID： PMC96840     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  36 in total

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Authors:  W P Kolb; L M Kolb; E R Podack
Journal:  J Immunol       Date:  1979-05       Impact factor: 5.422

Review 2.  Disseminated gonococcal infection (DGI) and gonococcal arthritis (GCA): I. Bacteriology, epidemiology, host factors, pathogen factors, and pathology.

Authors:  B I Eisenstein; A T Masi
Journal:  Semin Arthritis Rheum       Date:  1981-02       Impact factor: 5.532

3.  Gonococcal septicaemia presenting as a subcutaneous abscess.

Authors:  N O Owino; D Goldmeier; R A Wall
Journal:  Br J Vener Dis       Date:  1981-04

4.  Serum complement levels in bacteremia due to gram-negative organisms.

Authors:  W R McCabe
Journal:  N Engl J Med       Date:  1973-01-04       Impact factor: 91.245

5.  Pelvic inflammatory disease isolates of Neisseria gonorrhoeae are distinguished by C1q-dependent virulence for newborn rats and by the sac-4 region.

Authors:  S Nowicki; P Ram; T Pham; P Goluszko; S Morse; G D Anderson; B Nowicki
Journal:  Infect Immun       Date:  1997-06       Impact factor: 3.441

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Authors:  S A Al-Suleiman; E M Grimes; H S Jonas
Journal:  Obstet Gynecol       Date:  1983-01       Impact factor: 7.661

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Authors:  P A Rice; D L Goldenberg
Journal:  Ann Intern Med       Date:  1981-08       Impact factor: 25.391

8.  Variability of the lytic susceptibility of Neisseria gonorrhoeae to human sera.

Authors:  E C Tramont; J C Sadoff; C Wilson
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

Review 9.  [Determination of pathogens in blood in disseminated gonococcal infection. Case report and overview of the literature].

Authors:  H C Korting; U Neubert; O Braun-Falco
Journal:  Hautarzt       Date:  1983-08       Impact factor: 0.751

10.  Activation of complement by serum-resistant Neisseria gonorrhoeae. Assembly of the membrane attack complex without subsequent cell death.

Authors:  G R Harriman; E R Podack; A I Braude; L C Corbeil; A F Esser; J G Curd
Journal:  J Exp Med       Date:  1982-10-01       Impact factor: 14.307
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  3 in total

1.  Kinetics of Bartonella birtlesii infection in experimentally infected mice and pathogenic effect on reproductive functions.

Authors:  H J Boulouis; F Barrat; D Bermond; F Bernex; D Thibault; R Heller; J J Fontaine; Y Piémont; B B Chomel
Journal:  Infect Immun       Date:  2001-09       Impact factor: 3.441

2.  Preterm labor: CD55 in maternal blood leukocytes.

Authors:  Stella Nowicki; Michael G Izban; Edyta Pawelczyk; Vincent K Agboto; Siddarth Pratap; Gayle Olson; Bogdan Nowicki
Journal:  Am J Reprod Immunol       Date:  2009-05       Impact factor: 3.886

Review 3.  Role of Maternal Infections and Inflammatory Responses on Craniofacial Development.

Authors:  Anjali Y Bhagirath; Manoj Reddy Medapati; Vivianne Cruz de Jesus; Sneha Yadav; Martha Hinton; Shyamala Dakshinamurti; Devi Atukorallaya
Journal:  Front Oral Health       Date:  2021-09-06
  3 in total

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