Literature DB >> 10456326

Detection of a novel plasma serine protease during purification of vitamin K-dependent coagulation factors.

A Hunfeld1, M Etscheid, H König, R Seitz, J Dodt.   

Abstract

A novel serine protease (PHBSP) was purified from human plasma by two chromatographic steps with a final yield of 1.6 mg/l plasma. The protease consists of two disulfide-bridged chains of about 50 and 30 kDa with the light chain containing the active site of the enzyme. NH2-terminal sequence analysis revealed identity to the deduced amino acid sequence of HGFA-like mRNA. The activity of PHBSP is strongly dependent on Ca2+ ions and is efficiently inhibited by alpha2-antiplasmin and aprotinin. Possible functions of PHBSP in the hemostatic system are discussed.

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Year:  1999        PMID： 10456326     DOI： 10.1016/s0014-5793(99)00959-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Role of glycine 221 in catalytic activity of hyaluronan-binding protein 2.

Authors:  Fabian Stavenuiter; Eduard H T M Ebberink; Koen Mertens; Alexander B Meijer
Journal:  J Biol Chem       Date:  2017-02-27       Impact factor: 5.157

2.  Parallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma.

Authors:  Sylwia Modrzycka; Sonia Kołt; Stéphanie G I Polderdijk; Ty E Adams; Stanisław Potoczek; James A Huntington; Paulina Kasperkiewicz; Marcin Drąg
Journal:  Chem Sci       Date:  2022-04-27       Impact factor: 9.969

3.  Tissue factor pathway inhibitor is an inhibitor of factor VII-activating protease.

Authors:  F Stephan; I Dienava-Verdoold; I Bulder; D Wouters; A E Mast; H Te Velthuis; L A Aarden; S Zeerleder
Journal:  J Thromb Haemost       Date:  2012-06       Impact factor: 5.824

4.  Activation of factor VII-activating protease in human inflammation: a sensor for cell death.

Authors:  Femke Stephan; Jan A Hazelzet; Ingrid Bulder; Marja A Boermeester; Jw Olivier van Till; Tom van der Poll; Walter A Wuillemin; Lucien A Aarden; Sacha Zeerleder
Journal:  Crit Care       Date:  2011-04-05       Impact factor: 9.097

5.  Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome.

Authors:  Malgorzata Wygrecka; Rory E Morty; Philipp Markart; Sandip M Kanse; Peter A Andreasen; Troels Wind; Andreas Guenther; Klaus T Preissner
Journal:  J Biol Chem       Date:  2007-05-31       Impact factor: 5.157

6.  Proteolytic activation of the epithelial sodium channel (ENaC) by factor VII activating protease (FSAP) and its relevance for sodium retention in nephrotic mice.

Authors:  Ferruh Artunc; Bernhard N Bohnert; Jonas C Schneider; Tobias Staudner; Florian Sure; Alexandr V Ilyaskin; Matthias Wörn; Daniel Essigke; Andrea Janessa; Nis V Nielsen; Andreas L Birkenfeld; Michael Etscheid; Silke Haerteis; Christoph Korbmacher; Sandip M Kanse
Journal:  Pflugers Arch       Date:  2021-12-06       Impact factor: 4.458
  6 in total

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