J Finsterer1, B Mamoli. 1. Ludwig Boltzmann Institute for epilepsy and neuromuscular disorders, NKG Rosenhügel, Vienna, Austria.
Abstract
OBJECTIVES: Liquorpheresis (CSF filtration) has been shown to be of benefit in various neurologic disorders, including sporadic ALS. Liquorpheresis in patients with familial ALS, has not been investigated so far. METHODS: A 52-year-old woman with familial ALS is reported who underwent liquorpheresis during 4 consecutive days. During this period, 875 ml CSF were filtered off via an intrathecal catheter and a combined mechanical and ionic filter by means of a bi-directional syringe pump. RESULTS: Immediately after treatment and 2 weeks later there was subjective, but no objective, improvement of her symptoms, assessed by the Norris score and measurements of the elbow extension, vital capacity, F-waves of both ulnar nerves and automatic EMG of the right brachial biceps and anterior tibial muscles. CONCLUSION: Liquorpheresis does not seem to be helpful in the treatment of familial ALS.
OBJECTIVES: Liquorpheresis (CSF filtration) has been shown to be of benefit in various neurologic disorders, including sporadic ALS. Liquorpheresis in patients with familial ALS, has not been investigated so far. METHODS: A 52-year-old woman with familial ALS is reported who underwent liquorpheresis during 4 consecutive days. During this period, 875 ml CSF were filtered off via an intrathecal catheter and a combined mechanical and ionic filter by means of a bi-directional syringe pump. RESULTS: Immediately after treatment and 2 weeks later there was subjective, but no objective, improvement of her symptoms, assessed by the Norris score and measurements of the elbow extension, vital capacity, F-waves of both ulnar nerves and automatic EMG of the right brachial biceps and anterior tibial muscles. CONCLUSION: Liquorpheresis does not seem to be helpful in the treatment of familial ALS.
Authors: Jamie K Wong; Anna K Roselle; Taylor M Shue; Serena J E Shimshak; Joseph M Beaty; Nadia M Celestin; Ivy Gao; Rose P Griffin; Merit E Cudkowicz; Saud A Sadiq Journal: Brain Commun Date: 2022-08-22
Authors: Lucas R Sass; Mohammadreza Khani; Jacob Romm; Marianne Schmid Daners; Kyle McCain; Tavara Freeman; Gregory T Carter; Douglas L Weeks; Brian Petersen; Jason Aldred; Dena Wingett; Bryn A Martin Journal: Fluids Barriers CNS Date: 2020-01-21