Literature DB >> 10455279

Cross-resistance with dieldrin of a novel tricyclic dinitrile GABA receptor antagonist.

K Matsuda1, A M Hosie, C W Holyoke, J J Rauh, D B Sattelle.   

Abstract

A novel tricyclic dinitrile, KN244, blocked the wild-type (dieldrin-sensitive) homo-oligomeric gamma-aminobutyric acid (GABA)-gated chloride channel of Drosophila melanogaster expressed in Xenopus oocytes. Sensitivity to the block by KN244 of the response to 30 microM GABA (IC50=41.6 nM, wild-type RDLac) was reduced abut 100 fold (IC50=4.5 microM) in the dieldrin-resistant (RDLacA302S) form of RDL.

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Year:  1999        PMID： 10455279      PMCID： PMC1760657          DOI： 10.1038/sj.bjp.0702663

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  Studies on the mechanism of action of picrotoxinin and other convulsants at the crustacean muscle GABA receptor.

Authors:  T G Smart; A Constanti
Journal:  Proc R Soc Lond B Biol Sci       Date:  1986-03-22

2.  Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes.

Authors:  A M Hosie; Y Shirai; S D Buckingham; J J Rauh; R T Roush; H A Baylis; D B Sattelle
Journal:  Brain Res       Date:  1995-09-25       Impact factor: 3.252

Review 3.  Molecular biology of insect neuronal GABA receptors.

Authors:  A M Hosie; K Aronstein; D B Sattelle; R H ffrench-Constant
Journal:  Trends Neurosci       Date:  1997-12       Impact factor: 13.837

4.  Molecular cloning and transformation of cyclodiene resistance in Drosophila: an invertebrate gamma-aminobutyric acid subtype A receptor locus.

Authors:  R H Ffrench-Constant; D P Mortlock; C D Shaffer; R J MacIntyre; R T Roush
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

5.  A point mutation in a Drosophila GABA receptor confers insecticide resistance.

Authors:  R H Ffrench-Constant; T A Rocheleau; J C Steichen; A E Chalmers
Journal:  Nature       Date:  1993-06-03       Impact factor: 49.962

6.  Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster.

Authors:  A M Hosie; H A Baylis; S D Buckingham; D B Sattelle
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739

7.  Actions of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster.

Authors:  Y Shirai; A M Hosie; S D Buckingham; C W Holyoke; H A Baylis; D B Sattelle
Journal:  Neurosci Lett       Date:  1995-04-07       Impact factor: 3.046

8.  Polycyclic dinitriles: a novel class of potent GABAergic insecticides provides a new radioligand, [3H]BIDN.

Authors:  J J Rauh; C W Holyoke; D A Kleier; J K Presnail; E A Benner; D Cordova; M H Howard; A M Hosie; S D Buckingham; H A Baylis; D B Sattelle
Journal:  Invert Neurosci       Date:  1997 Sep-Dec
  8 in total
  1 in total

1.  Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels.

Authors:  Yan Xu; Shogo Furutani; Makoto Ihara; Yun Ling; Xinling Yang; Kenji Kai; Hideo Hayashi; Kazuhiko Matsuda
Journal:  PLoS One       Date:  2015-04-22       Impact factor: 3.240
  1 in total

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