Literature DB >> 10454123

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis.

W K Chung1, A Luke, R S Cooper, C Rotini, A Vidal-Puig, M Rosenbaum, D Gordon, S M Leal, S Caprio, R Goldsmith, A L Andreu, C Bruno, S DiMauro, M Heo, W L Lowe, B B Lowell, D B Allison, R L Leibel.   

Abstract

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3> have been described in humans, but not in rodents. The functional consequences-or lack thereof-of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

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Year:  1999        PMID： 10454123      PMCID： PMC6217808          DOI： 10.1038/sj.ijo.0800945

Source DB:  PubMed          Journal:  Int J Obes Relat Metab Disord


  13 in total

1.  Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis.

Authors:  R E Gimeno; M Dembski; X Weng; N Deng; A W Shyjan; C J Gimeno; F Iris; S J Ellis; E A Woolf; L A Tartaglia
Journal:  Diabetes       Date:  1997-05       Impact factor: 9.461

2.  Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance.

Authors:  S A Urhammer; L T Dalgaard; T I Sørensen; A M Møller; T Andersen; A Tybjaerg-Hansen; T Hansen; J O Clausen; H Vestergaard; O Pedersen
Journal:  Diabetologia       Date:  1997-10       Impact factor: 10.122

3.  Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.

Authors:  K Walder; R A Norman; R L Hanson; P Schrauwen; M Neverova; C P Jenkinson; J Easlick; C H Warden; C Pecqueur; S Raimbault; D Ricquier; M H Silver; A R Shuldiner; G Solanes; B B Lowell; W K Chung; R L Leibel; R Pratley; E Ravussin
Journal:  Hum Mol Genet       Date:  1998-09       Impact factor: 6.150

4.  Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients.

Authors:  S Otabe; K Clement; S Dubois; F Lepretre; V Pelloux; R Leibel; W Chung; P Boutin; B Guy-Grand; P Froguel; F Vasseur
Journal:  Diabetes       Date:  1999-01       Impact factor: 9.461

5.  Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5.

Authors:  C Sirrenberg; M Endres; H Fölsch; R A Stuart; W Neupert; M Brunner
Journal:  Nature       Date:  1998-02-26       Impact factor: 49.962

6.  Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans.

Authors:  C Bouchard; L Pérusse; Y C Chagnon; C Warden; D Ricquier
Journal:  Hum Mol Genet       Date:  1997-10       Impact factor: 6.150

7.  Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression.

Authors:  O Boss; S Samec; A Paoloni-Giacobino; C Rossier; A Dulloo; J Seydoux; P Muzzin; J P Giacobino
Journal:  FEBS Lett       Date:  1997-05-12       Impact factor: 4.124

8.  UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue.

Authors:  A Vidal-Puig; G Solanes; D Grujic; J S Flier; B B Lowell
Journal:  Biochem Biophys Res Commun       Date:  1997-06-09       Impact factor: 3.575

9.  Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia.

Authors:  C Fleury; M Neverova; S Collins; S Raimbault; O Champigny; C Levi-Meyrueis; F Bouillaud; M F Seldin; R S Surwit; D Ricquier; C H Warden
Journal:  Nat Genet       Date:  1997-03       Impact factor: 38.330

10.  Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes.

Authors:  G Argyropoulos; A M Brown; S M Willi; J Zhu; Y He; M Reitman; S M Gevao; I Spruill; W T Garvey
Journal:  J Clin Invest       Date:  1998-10-01       Impact factor: 14.808
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  1 in total

1.  Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region.

Authors:  Gemma Solanes; Neus Pedraza; Verónica Calvo; Antonio Vidal-Puig; Bradford B Lowell; Francesc Villarroya
Journal:  Biochem J       Date:  2005-03-15       Impact factor: 3.857
  1 in total

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