| Literature DB >> 10452530 |
E M Zubin1, E A Romanova, E M Volkov, V N Tashlitsky, G A Korshunova, Z A Shabarova, T S Oretskaya.
Abstract
Oligonucleotide-peptide conjugates have several applications, including their potential use as improved antisense agents for interfering with the RNA function within cells. In order to provide robust and generally applicable conjugation chemistry, we developed a novel approach of fragment coupling of pre-synthesized peptides to the 2'-position of a selected nucleotide within an otherwise protected oligonucleotide chain attached to a solid support.Entities:
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Year: 1999 PMID： 10452530 DOI： 10.1016/s0014-5793(99)00921-7
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124