Literature DB >> 10451226

The relaxin-like factor is a hormone.

E E Büllesbach1, R Rhodes, B Rembiesa, C Schwabe.   

Abstract

The relaxin-like factor (RLF) circulates in the bloodstream of humans, interacts with a membrane protein with all the characteristics of ligand-receptor binding, and must therefore be considered a hormone by definition. The polyclonal antibody raised against synthetic human RLF showed no crossreactivity to other structurally related hormones, like insulin and relaxin. The sensitivity of this assay (ED50 at 100 pM) allowed the direct measurement of RLF concentrations in serum. The highest levels were detected in the serum of postpuberty males (190 pM), whereas in females and children, the RLF concentration was one order of magnitude lower.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10451226     DOI： 10.1385/ENDO:10:2:167

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  13 in total

1.  Molecular cloning and expression of the relaxin-like factor from the mouse testis.

Authors:  W Pusch; M Balvers; R Ivell
Journal:  Endocrinology       Date:  1996-07       Impact factor: 4.736

2.  Structure and expression of Leydig insulin-like peptide mRNA in the sheep.

Authors:  P J Roche; A Butkus; E M Wintour; G Tregear
Journal:  Mol Cell Endocrinol       Date:  1996-08-09       Impact factor: 4.102

3.  Relaxin-like factor: a highly specific and constitutive new marker for Leydig cells in the human testis.

Authors:  R Ivell; M Balvers; R Domagalski; H Ungefroren; N Hunt; W Schulze
Journal:  Mol Hum Reprod       Date:  1997-06       Impact factor: 4.025

4.  Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination.

Authors:  E E Büllesbach; C Schwabe
Journal:  J Biol Chem       Date:  1991-06-15       Impact factor: 5.157

5.  Relaxin-like factor gene is highly expressed in the bovine ovary of the cycle and pregnancy: sequence and messenger ribonucleic acid analysis.

Authors:  R Bathgate; M Balvers; N Hunt; R Ivell
Journal:  Biol Reprod       Date:  1996-12       Impact factor: 4.285

6.  Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development.

Authors:  S Zimmermann; P Schöttler; W Engel; I M Adham
Journal:  Mol Reprod Dev       Date:  1997-05       Impact factor: 2.609

7.  Structural organization of the porcine and human genes coding for a Leydig cell-specific insulin-like peptide (LEY I-L) and chromosomal localization of the human gene (INSL3).

Authors:  E Burkhardt; I M Adham; B Brosig; A Gastmann; M G Mattei; W Engel
Journal:  Genomics       Date:  1994-03-01       Impact factor: 5.736

8.  The human Leydig insulin-like (hLEY I-L) gene is expressed in the corpus luteum and trophoblast.

Authors:  L S Tashima; A D Hieber; F C Greenwood; G D Bryant-Greenwood
Journal:  J Clin Endocrinol Metab       Date:  1995-02       Impact factor: 5.958

9.  A novel Leydig cell cDNA-derived protein is a relaxin-like factor.

Authors:  E E Büllesbach; C Schwabe
Journal:  J Biol Chem       Date:  1995-07-07       Impact factor: 5.157

10.  Plasma immunoreactive relaxin levels in pregnant and nonpregnant women.

Authors:  E M O'Byrne; B T Carriere; L Sorensen; A Segaloff; C Schwabe; B G Steinetz
Journal:  J Clin Endocrinol Metab       Date:  1978-11       Impact factor: 5.958
View more
  2 in total

1.  Relationships of plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I concentrations with scrotal circumference and testicular weight in Japanese Black beef bull calves.

Authors:  Mitsuhiro Sakase; Keita Kitagawa; Masahiko Kibushi; Noritoshi Kawate; W W P N Weerakoon; M A Hannan; Namiko Kohama; Hiromichi Tamada
Journal:  J Reprod Dev       Date:  2018-07-06       Impact factor: 2.214

2.  Insulin-Like Peptide 3 (INSL3) Serum Concentration During Human Male Fetal Life.

Authors:  Steven M Harrison; Nicol Corbin Bush; Yi Wang; Zachary R Mucher; Armando J Lorenzo; Gwen M Grimsby; Bruce J Schlomer; Erika E Büllesbach; Linda A Baker
Journal:  Front Endocrinol (Lausanne)       Date:  2019-09-04       Impact factor: 5.555
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.