Literature DB >> 10450991

Tetrapeptide derived inhibitors of complexation of a class II MHC: the peptide backbone is not inviolate.

A B Jones1, J J Acton, M N Rivetna, R T Cummings, R M Cubbon, E A Nichols, C D Schwartz, L S Wicker, J D Hermes.   

Abstract

Major histocompatabilty (MHC) proteins rely heavily on peptide backbone recognition for ligation. Nonetheless, modifications to the polyamide backbone of a tetrapeptide ligand can be made without abrogating binding.

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Year:  1999        PMID: 10450991     DOI: 10.1016/s0960-894x(99)00333-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease.

Authors:  Jiang Xia; Elin Bergseng; Burkhard Fleckenstein; Matthew Siegel; Chu-Young Kim; Chaitan Khosla; Ludvig M Sollid
Journal:  Bioorg Med Chem       Date:  2007-07-25       Impact factor: 3.641

2.  Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin.

Authors:  Jiang Xia; Matthew Siegel; Elin Bergseng; Ludvig M Sollid; Chaitan Khosla
Journal:  J Am Chem Soc       Date:  2006-02-15       Impact factor: 15.419

  2 in total

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