| Literature DB >> 10450984 |
H S Ahn1, L Arik, G Boykow, D A Burnett, M A Caplen, M Czarniecki, M S Domalski, C Foster, M Manna, A W Stamford, Y Wu.
Abstract
A series of pyrroloquinazolines has been discovered that represent novel small molecule inhibitors of the intramolecular ligand of the thrombin receptor. Analogs were prepared to study the structure-activity relationships of substitution at the N 1, N3, and N7 positions of the heterocycle. Compounds 4e and 4f have been identified with IC50's of 56 and 52 nM, respectively.Entities:
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Year: 1999 PMID： 10450984 DOI： 10.1016/s0960-894x(99)00339-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823