Literature DB >> 10450982

Synthesis of delta4-beta-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition.

P Florio1, R J Thomson, A Alafaci, S Abo, M von Itzstein.   

Abstract

Mimetics of Neu5Ac2en and KDN2en, based on delta4-beta-delta-glucopyranosiduronic acids, have been synthesised. The Neu5Ac2en mimetic 5 showed inhibition of both bacterial and viral sialidases, with inhibition of the viral sialidase being comparable to that of Neu5Ac2en itself.

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Year:  1999        PMID： 10450982     DOI： 10.1016/s0960-894x(99)00331-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Unsaturated N-acetyl- D-glucosaminuronic acid glycosides as inhibitors of influenza virus sialidase.

Authors:  Maretta C Mann; Tasneem Islam; Jeffrey C Dyason; Pas Florio; Carolyn J Trower; Robin J Thomson; Mark von Itzstein
Journal:  Glycoconj J       Date:  2006-02       Impact factor: 2.916

2.  Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2.

Authors:  Aleksander Hinek; Tetyana D Bodnaruk; Severa Bunda; Yanting Wang; Kela Liu
Journal:  Am J Pathol       Date:  2008-09-04       Impact factor: 4.307
  2 in total

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