Literature DB >> 10450981

Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonist.

T Dubuffet1, A Newman-Tancredi, D Cussac, V Audinot, A Loutz, M J Millan, G Lavielle.   

Abstract

A new series of benzopyrano[3,4-c]pyrrole derivatives were synthesized and evaluated for their interaction with dopamine D3 versus D2 receptors. Amongst these compounds, 4x (S 33084) was found to be a potent and selective dopamine D3 receptor antagonist.

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Year:  1999        PMID: 10450981     DOI: 10.1016/s0960-894x(99)00312-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

Review 1.  The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence.

Authors:  Christian A Heidbreder; Eliot L Gardner; Zheng-Xiong Xi; Panayotis K Thanos; Manolo Mugnaini; Jim J Hagan; Charles R Ashby
Journal:  Brain Res Brain Res Rev       Date:  2005-07

Review 2.  Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders.

Authors:  Christian A Heidbreder; Amy H Newman
Journal:  Ann N Y Acad Sci       Date:  2010-02       Impact factor: 5.691

3.  One-pot multi-component synthesis of novel chromeno[4,3-b]pyrrol-3-yl derivatives as alpha-glucosidase inhibitors.

Authors:  Malihe Karami; Alireza Hasaninejad; Hossein Mahdavi; Aida Iraji; Somayeh Mojtabavi; Mohammad Ali Faramarzi; Mohammad Mahdavi
Journal:  Mol Divers       Date:  2021-10-25       Impact factor: 3.364

Review 4.  Neurobiological and Pharmacological Perspectives of D3 Receptors in Parkinson's Disease.

Authors:  Abdeslam Chagraoui; Giuseppe Di Giovanni; Philippe De Deurwaerdère
Journal:  Biomolecules       Date:  2022-02-01

5.  Titania-promoted carboxylic acid alkylations of alkenes and cascade addition-cyclizations.

Authors:  David W Manley; Roy T McBurney; Phillip Miller; John C Walton; Andrew Mills; Christopher O'Rourke
Journal:  J Org Chem       Date:  2014-01-28       Impact factor: 4.354

  5 in total

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