| Literature DB >> 10450966 |
S Kuroda1, A Akahane, H Itani, S Nishimura, K Durkin, T Kinoshita, Y Tenda, K Sakane.
Abstract
Novel 3-(2-cycloalkyl and cycloalkenyl-3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazo lo [1,5-a]-pyridines were synthesized and evaluated for their adenosine A1 receptor binding activities. In this series, FR166124 (3) was found to be the most potent and selective adenosine A1 receptor antagonist, and the double bond of the cyclohexenyl acetic acid group was essential for selectivity of A1 receptor binding. Furthermore, the solubility in water of the sodium salt of FR 166124 was high.Entities:
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Year: 1999 PMID： 10450966 DOI： 10.1016/s0960-894x(99)00304-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823