Literature DB >> 10450373

The National Diabetic Retinopathy Laser Treatment Audit. III. Clinical outcomes.

C C Bailey1, J M Sparrow, R H Grey, H Cheng.   

Abstract

PURPOSE: To describe the short-term clinical outcomes for a cohort of patients undergoing first photocoagulation treatment for proliferative retinopathy or maculopathy in the United Kingdom.
METHOD: Nine-month follow-up of the Royal College of Ophthalmologists' national audit of laser treatment for diabetic retinopathy.
RESULTS: For eyes with maculopathy, 9.2% had had a deterioration in visual acuity equivalent to a doubling of the visual angle and 3.3% of eyes had a visual acuity of less than 6/60 at follow-up. There had been an improvement in the macular oedema or exudate in 64.6% and 77.3% respectively. Prognostic factors for a poorer visual acuity at follow-up were worse visual acuity at baseline, the presence of diffuse (vs focal) oedema and grid (vs focal) treatment. For eyes with proliferative retinopathy, the retinal neovascularisation had regressed fully in 50.8% of cases, whilst there had been no change or a deterioration in 10.3%. A visual acuity of less than 6/60 at follow-up was present in 8.6% of eyes. There was a poor morphological outcome at follow-up (as defined by rubeosis, new tractional detachment or having had a vitrectomy) in 7.2%. Risk factors for poor morphological outcome were the presence of 'high-risk characteristics', female sex and the presence of concurrent maculopathy at baseline. Regression of neovascularisation was associated with greater areas of retinal ablation at the initial treatment session. Although some eyes with proliferative retinopathy appeared to be undertreated initially compared with DRS and ETDRS protocols, some of these eyes did respond to lower amounts of treatment.
CONCLUSION: For maculopathy, poorer outcome was related to worse visual acuity at baseline, diffuse (vs focal) maculopathy, and grid treatment. For proliferative retinopathy, poorer outcome was related to 'high-risk characteristics' and coexistence of maculopathy at baseline, and improvement was related to larger areas of ablation. The relationship of poor outcome with worse initial disease argues for earlier detection of retinopathy.

Entities:  

Mesh:

Year:  1999        PMID: 10450373     DOI: 10.1038/eye.1999.42

Source DB:  PubMed          Journal:  Eye (Lond)        ISSN: 0950-222X            Impact factor:   3.775


  20 in total

1.  Interpreting thickness changes in the diabetic macula: the problem of short-term variation in optical coherence tomography-measured macular thickening (an american ophthalmological society thesis).

Authors:  David J Browning
Journal:  Trans Am Ophthalmol Soc       Date:  2010-12

2.  Pascal panretinal laser ablation and regression analysis in proliferative diabetic retinopathy: Manchester Pascal Study Report 4.

Authors:  M M K Muqit; G R Marcellino; D B Henson; L B Young; G S Turner; P E Stanga
Journal:  Eye (Lond)       Date:  2011-08-05       Impact factor: 3.775

3.  The retinal disease screening study: prospective comparison of nonmydriatic fundus photography and optical coherence tomography for detection of retinal irregularities.

Authors:  Yanling Ouyang; Florian M Heussen; Pearse A Keane; Srinivas R Sadda; Alexander C Walsh
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-02-19       Impact factor: 4.799

4.  Decreased circulation in the feline choriocapillaris underlying retinal photocoagulation lesions.

Authors:  Christine J Lee; Jennifer H Smith; Jennifer J Kang-Mieler; Ewa Budzynski; Robert A Linsenmeier
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-05-01       Impact factor: 4.799

Review 5.  [Microvascular and macrovascular complications in children and adolescents with type 1 diabetes mellitus].

Authors:  Elke E Fröhlich-Reiterer; Martin H Borkenstein
Journal:  Wien Med Wochenschr       Date:  2010-08

6.  Elevations of AGE and vascular endothelial growth factor with decreased total antioxidant status in the vitreous fluid of diabetic patients with retinopathy.

Authors:  M Yokoi; S-I Yamagishi; M Takeuchi; K Ohgami; T Okamoto; W Saito; M Muramatsu; T Imaizumi; S Ohno
Journal:  Br J Ophthalmol       Date:  2005-06       Impact factor: 4.638

7.  Association of the extent of diabetic macular edema as assessed by optical coherence tomography with visual acuity and retinal outcome variables.

Authors:  David J Browning; Rajendra S Apte; Susan B Bressler; Kakarla V Chalam; Ronald P Danis; Matthew D Davis; Craig Kollman; Haijing Qin; Srinivas Sadda; Ingrid U Scott
Journal:  Retina       Date:  2009-03       Impact factor: 4.256

8.  [Diagnosis, therapy and follow up of diabetic eye disease].

Authors:  Michael Stur; Stefan Egger; Anton Haas; Gerhard Kieselbach; Stefan Mennel; Reinhard Michl; Michael Roden; Ulrike Stolba; Andreas Wedrich
Journal:  Wien Klin Wochenschr       Date:  2012-12       Impact factor: 1.704

9.  Teleretinal imaging to screen for diabetic retinopathy in the Veterans Health Administration.

Authors:  Anthony A Cavallerano; Paul R Conlin
Journal:  J Diabetes Sci Technol       Date:  2008-01

10.  Pascal laser versus conventional laser for treatment of diabetic retinopathy.

Authors:  Abdelrahman G Salman
Journal:  Saudi J Ophthalmol       Date:  2011-01-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.