PURPOSE: The nature of the resection in surgery for intractable medial temporal lobe epilepsy is likely to be a principal factor determining seizure and neuropsychological outcome. However, there is no universally accepted system for describing the characteristics of individual resections to allow comparison between patients and patient groups treated at different institutions. We therefore developed a technique of volumetric analysis of temporal lobe resections. METHODS: With comparison of coregistered pre- and postoperative, volumetric magnetic resonance imaging (MRI) scans in 10 subjects, the volumes of six temporal lobe substructures were determined by manual delineation in the pre- and post-operative images for each case, allowing the extent of resection to be determined. RESULTS: The substructures and their extent of resection were measured with acceptable repeatability in each case. CONCLUSIONS: We developed a reliable method for the quantitative description of temporal lobe resections. This will be of application in determining the relation between the anatomic nature of the resection in intractable epilepsy and the seizure and neuropsychological outcome.
PURPOSE: The nature of the resection in surgery for intractable medial temporal lobe epilepsy is likely to be a principal factor determining seizure and neuropsychological outcome. However, there is no universally accepted system for describing the characteristics of individual resections to allow comparison between patients and patient groups treated at different institutions. We therefore developed a technique of volumetric analysis of temporal lobe resections. METHODS: With comparison of coregistered pre- and postoperative, volumetric magnetic resonance imaging (MRI) scans in 10 subjects, the volumes of six temporal lobe substructures were determined by manual delineation in the pre- and post-operative images for each case, allowing the extent of resection to be determined. RESULTS: The substructures and their extent of resection were measured with acceptable repeatability in each case. CONCLUSIONS: We developed a reliable method for the quantitative description of temporal lobe resections. This will be of application in determining the relation between the anatomic nature of the resection in intractable epilepsy and the seizure and neuropsychological outcome.
Authors: Tejal N Mitchell; Samantha L Free; Martin Merschhemke; Louis Lemieux; Sanjay M Sisodiya; Simon D Shorvon Journal: AJNR Am J Neuroradiol Date: 2003-03 Impact factor: 3.825
Authors: Mahinda Yogarajah; Niels K Focke; Silvia B Bonelli; Pamela Thompson; Christian Vollmar; Andrew W McEvoy; Daniel C Alexander; Mark R Symms; Matthias J Koepp; John S Duncan Journal: Brain Date: 2010-08 Impact factor: 13.501
Authors: M Yogarajah; N K Focke; S Bonelli; M Cercignani; J Acheson; G J M Parker; D C Alexander; A W McEvoy; M R Symms; M J Koepp; J S Duncan Journal: Brain Date: 2009-05-21 Impact factor: 13.501
Authors: Alexander Hammers; Richard Allom; Matthias J Koepp; Samantha L Free; Ralph Myers; Louis Lemieux; Tejal N Mitchell; David J Brooks; John S Duncan Journal: Hum Brain Mapp Date: 2003-08 Impact factor: 5.038
Authors: M Yogarajah; H W R Powell; G J M Parker; D C Alexander; P J Thompson; M R Symms; P Boulby; C A Wheeler-Kingshott; G J Barker; M J Koepp; J S Duncan Journal: Neuroimage Date: 2008-01-10 Impact factor: 6.556