Literature DB >> 10447756

The influence of complement receptor type 1 (CD35) and decay-accelerating factor (CD55) on complement receptor type 2- (CD21) mediated alternative pathway activation by B cells.

R G Leslie1.   

Abstract

The influence of complement receptor type 1 (CR1; CD35) and decay-accelerating factor (DAF; CD55), both down-regulators of complement activation, on the complement receptor type 2- (CR2) mediated alternative pathway (AP) activation of complement on normal B cells, was assessed. The data indicate that, while neither DAF nor CR1 hinder the function of the AP convertase formed on CR2, CR1 plays a significant role in the remodelling of C3b fragments, generated by the convertase and deposited at secondary acceptor sites on the B-cell surface, such that they become suitable ligands for CR2. The significance of this finding is briefly discussed.

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Year:  1999        PMID： 10447756      PMCID： PMC2326846          DOI： 10.1046/j.1365-2567.1999.00846.x

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  9 in total

1.  A comparative study of normal B cells and the EBV-positive Burkitt's lymphoma cell line, Raji, as activators of the complement system.

Authors:  H V Marquart; E H Olesen; A A Johnson; G Damgaard; R G Leslie
Journal:  Scand J Immunol       Date:  1997-09       Impact factor: 3.487

2.  Activation of the alternative complement pathway by lymphoblastoid cell lines derived from patients with Burkitt's lymphoma and infectious mononucleosis.

Authors:  D B Budzko; P J Lachmann; I McConnell
Journal:  Cell Immunol       Date:  1976-03-01       Impact factor: 4.868

3.  A novel mechanism of alternative pathway complement activation accounts for the deposition of C3 fragments on CR2-expressing homologous cells.

Authors:  M G Schwendinger; M Spruth; J Schoch; M P Dierich; W M Prodinger
Journal:  J Immunol       Date:  1997-06-01       Impact factor: 5.422

Review 4.  The role of complement and complement receptors in induction and regulation of immunity.

Authors:  M C Carroll
Journal:  Annu Rev Immunol       Date:  1998       Impact factor: 28.527

5.  Generation of three different fragments of bound C3 with purified factor I or serum. I. Requirements for factor H vs CR1 cofactor activity.

Authors:  G D Ross; J D Lambris; J A Cain; S L Newman
Journal:  J Immunol       Date:  1982-11       Impact factor: 5.422

6.  Quantitative measurement of Fc receptor activity on human peripheral blood monocytes and the monocyte-like cell line, U937, by laser flow cytometry.

Authors:  J Christensen; R G Leslie
Journal:  J Immunol Methods       Date:  1990-09-14       Impact factor: 2.303

7.  A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells.

Authors:  K Kerekes; J Prechl; Z Bajtay; M Józsi; A Erdei
Journal:  Int Immunol       Date:  1998-12       Impact factor: 4.823

8.  Evidence for distinct intracellular pools of receptors for C3b and C3bi in human neutrophils.

Authors:  J J O'Shea; E J Brown; B E Seligmann; J A Metcalf; M M Frank; J I Gallin
Journal:  J Immunol       Date:  1985-04       Impact factor: 5.422

9.  CR2 is the primary acceptor site for C3 during alternative pathway activation of complement on human peripheral B lymphocytes.

Authors:  H V Marquart; S E Svehag; R G Leslie
Journal:  J Immunol       Date:  1994-07-01       Impact factor: 5.422
  9 in total
  4 in total

Review 1.  The role of complement in the acquired immune response.

Authors:  C H Nielsen; E M Fischer; R G Leslie
Journal:  Immunology       Date:  2000-05       Impact factor: 7.397

2.  CR2-mediated activation of the complement alternative pathway results in formation of membrane attack complexes on human B lymphocytes.

Authors:  C H Nielsen; H V Marquart; W M Prodinger; R G Leslie
Journal:  Immunology       Date:  2001-12       Impact factor: 7.397

3.  The classical and alternative pathways of complement activation play distinct roles in spontaneous C3 fragment deposition and membrane attack complex (MAC) formation on human B lymphocytes.

Authors:  Robert Graham Quinton Leslie; Claus Henrik Nielsen
Journal:  Immunology       Date:  2004-01       Impact factor: 7.397

4.  Spontaneous complement activation on human B cells results in localized membrane depolarization and the clustering of complement receptor type 2 and C3 fragments.

Authors:  Morten Løbner; Robert G Q Leslie; Wolfgang M Prodinger; Claus H Nielsen
Journal:  Immunology       Date:  2009-01-23       Impact factor: 7.397
  4 in total

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