Literature DB >> 10446652

IFN gamma inhibits porcine reproductive and respiratory syndrome virus replication in macrophages.

E M Bautista1, T W Molitor.   

Abstract

This study reports the effect of IFN gamma on the replication of porcine reproductive and respiratory syndrome virus (PRRSV) in macrophages. Pretreatment with IFN gamma profoundly affected PRRSV replication in porcine macrophages evaluated by reduction in titer and percentage of positive cells. The effect of IFN gamma on PRRSV replication was both dose-dependent and related to the time of exposure. The mechanism of action was not due to blocking virus attachment. The inhibitory effect on PRRSV replication in macrophages suggests that IFN gamma may play an important role in protection.

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Year:  1999        PMID： 10446652     DOI： 10.1007/s007050050578

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  32 in total

1.  The cysteine protease domain of porcine reproductive and respiratory syndrome virus nonstructural protein 2 possesses deubiquitinating and interferon antagonism functions.

Authors:  Zhi Sun; Zhenhai Chen; Steven R Lawson; Ying Fang
Journal:  J Virol       Date:  2010-05-26       Impact factor: 5.103

2.  Cytokine profiles in peripheral blood mononuclear cells and lymph node cells from piglets infected in utero with porcine reproductive and respiratory syndrome virus.

Authors:  B Aasted; P Bach; J Nielsen; P Lind
Journal:  Clin Diagn Lab Immunol       Date:  2002-11

3.  Virological and immunological responses to porcine reproductive and respiratory syndrome virus in a large population of gilts.

Authors:  Laura Batista; Carlos Pijoan; Scott Dee; Michael Olin; Thomas Molitor; Han Soo Joo; Zhenguo Xiao; Michael Murtaugh
Journal:  Can J Vet Res       Date:  2004-10       Impact factor: 1.310

4.  Comparative measurement of cell-mediated immune responses of swine to the M and N proteins of porcine reproductive and respiratory syndrome virus.

Authors:  Hyun-Jeong Jeong; Young-Jo Song; Sang-Won Lee; Joong-Bok Lee; Seung-Yong Park; Chang-Seon Song; Gun-Woo Ha; Jin-Sik Oh; Youn-Kyoung Oh; In-Soo Choi
Journal:  Clin Vaccine Immunol       Date:  2010-02-03

5.  Evaluation of a DNA vaccine candidate co-expressing GP3 and GP5 of porcine reproductive and respiratory syndrome virus (PRRSV) with interferon α/γ in immediate and long-lasting protection against HP-PRRSV challenge.

Authors:  Yijun Du; Jing Qi; Yu Lu; Jiaqiang Wu; Dongwan Yoo; Xing Liu; Xiumei Zhang; Jun Li; Wenbo Sun; Xiaoyan Cong; Jianli Shi; Jinbao Wang
Journal:  Virus Genes       Date:  2012-07-28       Impact factor: 2.332

6.  The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load.

Authors:  Zhengguo Xiao; Laura Batista; Scott Dee; Patrick Halbur; Michael P Murtaugh
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

7.  Effects of Astragalus polysaccharide on immune responses of porcine PBMC stimulated with PRRSV or CSFV.

Authors:  Zeng-Yu Zhuge; Yao-Hong Zhu; Pan-Qi Liu; Xiao-Dong Yan; Yuan Yue; Xiao-Gang Weng; Rong Zhang; Jiu-Feng Wang
Journal:  PLoS One       Date:  2012-01-09       Impact factor: 3.240

8.  Vaccination of sows against type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) before artificial insemination protects against type 2 PRRSV challenge but does not protect against type 1 PRRSV challenge in late gestation.

Authors:  Kiwon Han; Hwi Won Seo; Changhoon Park; Chanhee Chae
Journal:  Vet Res       Date:  2014-02-02       Impact factor: 3.683

9.  Emergency vaccination alleviates highly pathogenic porcine reproductive and respiratory syndrome virus infection after contact exposure.

Authors:  Xiao Li; Li Qiu; Zengqi Yang; Ruiyi Dang; Xinglong Wang
Journal:  BMC Vet Res       Date:  2013-02-09       Impact factor: 2.741

10.  Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection.

Authors:  Nicholas J Boddicker; Angelica Bjorkquist; Raymond R R Rowland; Joan K Lunney; James M Reecy; Jack C M Dekkers
Journal:  Genet Sel Evol       Date:  2014-03-04       Impact factor: 4.297
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