| Literature DB >> 10446287 |
Y Sokolov1, T Mirzabekov, D W Martin, R I Lehrer, B L Kagan.
Abstract
Protegrins are small, arginine- and cysteine-rich, beta-sheet peptides with potent activity against bacteria, fungi, and certain enveloped viruses. We report that protegrins form weakly anion-selective channels in planar phospholipid bilayers, induce potassium leakage from liposomes and form moderately cation-selective channels in planar lipid membranes that contain bacterial lipopolysaccharide. The disruption of microbial membranes may be a central attribute related to the host defense properties of protegrins.Entities:
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Year: 1999 PMID： 10446287 DOI： 10.1016/s0005-2736(99)00086-3
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002