UNLABELLED: Technical developments in immunophenotyping and function testing have greatly facilitated studies on the developing lymphocyte system in the past decade and contributed to a better interpretation of the data obtained in these studies. This is important for the correct interpretation of data obtained in paediatric patients with possible immunological diseases. The age-related differences in lymphocyte subpopulations and function imply that the available adult reference values cannot be used in children. CONCLUSION: In this review we give an outline of the technical developments, their influence upon the interpretation of data, and the available literature about age-related changes in the developing lymphocyte system.
UNLABELLED: Technical developments in immunophenotyping and function testing have greatly facilitated studies on the developing lymphocyte system in the past decade and contributed to a better interpretation of the data obtained in these studies. This is important for the correct interpretation of data obtained in paediatric patients with possible immunological diseases. The age-related differences in lymphocyte subpopulations and function imply that the available adult reference values cannot be used in children. CONCLUSION: In this review we give an outline of the technical developments, their influence upon the interpretation of data, and the available literature about age-related changes in the developing lymphocyte system.
Authors: Evelien R van Meel; Sara M Mensink-Bout; Herman T den Dekker; Tarunveer S Ahluwalia; Isabella Annesi-Maesano; Syed Hasan Arshad; Nour Baïz; Henrique Barros; Andrea von Berg; Hans Bisgaard; Klaus Bønnelykke; Christian J Carlsson; Maribel Casas; Leda Chatzi; Cecile Chevrier; Geertje Dalmeijer; Carol Dezateux; Karel Duchen; Merete Eggesbø; Cornelis van der Ent; Maria Fantini; Claudia Flexeder; Urs Frey; Fransesco Forastiere; Ulrike Gehring; Davide Gori; Raquel Granell; Lucy J Griffiths; Hazel Inskip; Joanna Jerzynska; Anne M Karvonen; Thomas Keil; Cecily Kelleher; Manolis Kogevinas; Gudrun Koppen; Claudia E Kuehni; Nathalie Lambrechts; Susanne Lau; Irina Lehmann; Johnny Ludvigsson; Maria Christine Magnus; Erik Mélen; John Mehegan; Monique Mommers; Anne-Marie Nybo Andersen; Wenche Nystad; Eva S L Pedersen; Juha Pekkanen; Ville Peltola; Katharine C Pike; Angela Pinot de Moira; Costanza Pizzi; Kinga Polanska; Maja Popovic; Daniela Porta; Graham Roberts; Ana Cristina Santos; Erica S Schultz; Marie Standl; Jordi Sunyer; Carel Thijs; Laura Toivonen; Eleonora Uphoff; Jakob Usemann; Marina Vafeidi; John Wright; Johan C de Jongste; Vincent W V Jaddoe; Liesbeth Duijts Journal: Eur Respir J Date: 2022-10-06 Impact factor: 33.795
Authors: Evelien R van Meel; Herman T den Dekker; Niels J Elbert; Pauline W Jansen; Henriëtte A Moll; Irwin K Reiss; Johan C de Jongste; Vincent W V Jaddoe; Liesbeth Duijts Journal: Thorax Date: 2017-11-03 Impact factor: 9.139