Hyaluronic acid and chemoattractant substance from follicular fluid: in vitro effect of human sperm migration.

The glycoaminoglycans hyaluronic acid (HA) has been described in human follicular fluid and its effect on spermatozoa motility was previously described. In an in vitro model, the number of human spermatozoa migrating to wells containing HA was significantly higher than the number migrating to control wells. Time- and concentration-dependent effects of HA on directional migration of spermatozoa indicate a chemotactical character of observed phenomenon.