| Literature DB >> 10445035 |
Y Jin1, Y Wang, D L Walker, H Dong, C Conley, J Johansen, K M Johansen.
Abstract
We have cloned and characterized JIL-1, a novel tandem kinase in Drosophila that associates with the chromosomes throughout the cell cycle. Antibody staining and live imaging of JIL-1-GFP transgenic flies show that JIL-1 localizes to the gene-rich interband regions of larval polytene chromosomes and is upregulated almost 2-fold on the hypertranscribed male X chromosome compared to autosomes. Phylogenetic analysis suggests that JIL-1 together with human MSKs defines a separate family of tandem kinases. That JIL-1 is a functional kinase was demonstrated by autophosphorylation and phosphorylation of histone H3 in vitro. Based on these findings, we propose that JIL-1 may play a role in transcriptional control potentially by regulating chromatin structure.Entities:
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Year: 1999 PMID： 10445035 DOI： 10.1016/s1097-2765(00)80195-1
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970