HYPOTHESIS: There is an independent association between the different patterns of esophageal acid exposure in gastroesophageal reflux disease and the severity of the disease. DESIGN: Case-comparison study. SETTING: Department of surgery at a university hospital. PATIENTS: A group of 401 patients with increased esophageal acid exposure divided into 4 groups according to the pattern of reflux: postprandial (n = 41), upright (n = 74), supine (n = 129), and bipositional (n = 157). MAIN OUTCOME MEASURES: The prevalence of mucosal injury and the status of the lower esophageal sphincter and esophageal motility were assessed in each group. RESULTS: The likelihood of having indicators of the severity of gastroesophageal reflux disease increases progressively from postprandial to upright, supine, and bipositional reflux. CONCLUSIONS: The pattern of esophageal acid exposure in gastroesophageal reflux disease is an objective predictor of the severity of disease and could be used for therapeutic decisions.
HYPOTHESIS: There is an independent association between the different patterns of esophageal acid exposure in gastroesophageal reflux disease and the severity of the disease. DESIGN: Case-comparison study. SETTING: Department of surgery at a university hospital. PATIENTS: A group of 401 patients with increased esophageal acid exposure divided into 4 groups according to the pattern of reflux: postprandial (n = 41), upright (n = 74), supine (n = 129), and bipositional (n = 157). MAIN OUTCOME MEASURES: The prevalence of mucosal injury and the status of the lower esophageal sphincter and esophageal motility were assessed in each group. RESULTS: The likelihood of having indicators of the severity of gastroesophageal reflux disease increases progressively from postprandial to upright, supine, and bipositional reflux. CONCLUSIONS: The pattern of esophageal acid exposure in gastroesophageal reflux disease is an objective predictor of the severity of disease and could be used for therapeutic decisions.
Authors: Diana M Orbelo; Felicity T Enders; Yvonne Romero; Dawn L Francis; Sami R Achem; Tushar S Dabade; Michael D Crowell; Debra M Geno; Ramona S DeJesus; Vikneswaran Namasivayam; Steven C Adamson; Amindra S Arora; Andrew J Majka; Jeffrey A Alexander; Joseph A Murray; Matthew Lohse; Nancy N Diehl; Mary Fredericksen; Kee Wook Jung; Margaret S Houston; Angela E O'Neil; David A Katzka Journal: Dig Dis Sci Date: 2014-01-22 Impact factor: 3.199
Authors: Christian A Gutschow; Elfriede Bollschweiler; Wolfgang Schröder; Peter Collet; Jean-Marie Collard; Arnulf H Hölscher Journal: J Gastrointest Surg Date: 2005-04 Impact factor: 3.452
Authors: Theodore Liakakos; George Karamanolis; Paul Patapis; Evangelos P Misiakos Journal: Gastroenterol Res Pract Date: 2009-12-31 Impact factor: 2.260