OBJECTIVE: To determine the correlations between ophthalmoscopic estimations and the measurements with a semiautomated image-analysis device of the vertical cup-to-disc ratio (VCDR) in the human optic disc. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: All subjects 55 years of age and older from the population-based sample of 6777 ophthalmologically examined subjects from The Rotterdam Study of whom gradable optic disc transparencies of at least 1 eye and ophthalmoscopic data of the same eye were available. MAIN OUTCOME MEASURES: Ophthalmoscopic assessment of the VCDR and semiautomated measurement of the VCDR. METHODS: Indirect and direct ophthalmoscopy were performed in mydriasis to assess the VCDR. Optic disc transparencies made with a simultaneous stereoscopic telecentric fundus camera were analyzed with a semiautomated measurement system (Topcon Imagenet). RESULTS: In 5143 subjects, the mean ophthalmoscopic VCDR was 0.30 (standard error [SE], 0.0021; range, 0.00, 1.00) compared with a semiautomatically measured VCDR of 0.49 (SE, 0.0019; range, 0.04, 0.86; difference, 0.19; P < 0.0001). The overall correlation between both methods was moderate (correlation coefficient, 0.61; SE, 0.11) and lower in small optic discs. Semiautomated optic disc measurements correctly identified 76% of the glaucoma cases (as defined using visual field data and ophthalmoscopic data about the optic disc). CONCLUSION: Semiautomated measurements of the VCDR are larger than the ophthalmoscopic VCDR estimate with a moderate correlation. The interobserver variability using Imagenet was smaller compared with the ophthalmoscopic assessments, and Imagenet was better standardized, which is important for epidemiologic surveys and follow-up studies.
OBJECTIVE: To determine the correlations between ophthalmoscopic estimations and the measurements with a semiautomated image-analysis device of the vertical cup-to-disc ratio (VCDR) in the human optic disc. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: All subjects 55 years of age and older from the population-based sample of 6777 ophthalmologically examined subjects from The Rotterdam Study of whom gradable optic disc transparencies of at least 1 eye and ophthalmoscopic data of the same eye were available. MAIN OUTCOME MEASURES: Ophthalmoscopic assessment of the VCDR and semiautomated measurement of the VCDR. METHODS: Indirect and direct ophthalmoscopy were performed in mydriasis to assess the VCDR. Optic disc transparencies made with a simultaneous stereoscopic telecentric fundus camera were analyzed with a semiautomated measurement system (Topcon Imagenet). RESULTS: In 5143 subjects, the mean ophthalmoscopic VCDR was 0.30 (standard error [SE], 0.0021; range, 0.00, 1.00) compared with a semiautomatically measured VCDR of 0.49 (SE, 0.0019; range, 0.04, 0.86; difference, 0.19; P < 0.0001). The overall correlation between both methods was moderate (correlation coefficient, 0.61; SE, 0.11) and lower in small optic discs. Semiautomated optic disc measurements correctly identified 76% of the glaucoma cases (as defined using visual field data and ophthalmoscopic data about the optic disc). CONCLUSION: Semiautomated measurements of the VCDR are larger than the ophthalmoscopic VCDR estimate with a moderate correlation. The interobserver variability using Imagenet was smaller compared with the ophthalmoscopic assessments, and Imagenet was better standardized, which is important for epidemiologic surveys and follow-up studies.
Authors: Thasarat Sutabutr Vajaranant; Joelle Hallak; Mark A Espeland; Louis R Pasquale; Barbara E Klein; Stacy M Meuer; Stephen R Rapp; Mary N Haan; Pauline M Maki Journal: Am J Ophthalmol Date: 2019-06-01 Impact factor: 5.258
Authors: Catey Bunce; Roger A Hitchings; Cornelia M Van Duijn; Paulus T V M De Jong; Johannes R Vingerling Journal: Graefes Arch Clin Exp Ophthalmol Date: 2004-10-13 Impact factor: 3.117
Authors: George L Spaeth; Jeffrey Henderer; Connie Liu; Muge Kesen; Undraa Altangerel; Atilla Bayer; L Jay Katz; Jonathan Myers; Douglas Rhee; William Steinmann Journal: Trans Am Ophthalmol Soc Date: 2002
Authors: Xikun Han; Kaiah Steven; Ayub Qassim; Henry N Marshall; Cameron Bean; Michael Tremeer; Jiyuan An; Owen M Siggs; Puya Gharahkhani; Jamie E Craig; Alex W Hewitt; Maciej Trzaskowski; Stuart MacGregor Journal: Am J Hum Genet Date: 2021-06-01 Impact factor: 11.025