PURPOSE: The aim of this study was to analyze the incidence of postsplenectomy sepsis morbidity and mortality after prophylaxis, in comparison with our previous 13-year study (1958 to 1970, inclusive). METHODS: All patients who had splenectomy at the Hospital for Sick Children, Toronto, between 1971 and 1995, inclusive (to give a minimum of 2 years for follow-up), were reviewed for infection and mortality. The criterion for classifying a patient as "infected" was the recovery of an invading encapsulated organism from the blood culture in a patient admitted to the hospital. RESULTS: Of the 264 patients studied, 10 had a postsplenectomy infection (3.8%); nine occurred in patients who underwent splenectomy between the ages of 0 and 5 years. Infection took place within 2 +/- 3 years (mean +/- SD) after splenectomy for the immunized patients and 11 +/- 5 days (mean +/- SD) for the nonimmunized children. A significant number of patients were admitted for an apparent respiratory infection, but no serum organisms were isolated. One died of overwhelming sepsis, but the responsible organism was not identified. CONCLUSION: Although there has not been a decrease in the number of splenectomies performed per year, the incidence of infection and mortality has decreased by 47% and 88%, respectively, with prophylaxis.
PURPOSE: The aim of this study was to analyze the incidence of postsplenectomy sepsis morbidity and mortality after prophylaxis, in comparison with our previous 13-year study (1958 to 1970, inclusive). METHODS: All patients who had splenectomy at the Hospital for Sick Children, Toronto, between 1971 and 1995, inclusive (to give a minimum of 2 years for follow-up), were reviewed for infection and mortality. The criterion for classifying a patient as "infected" was the recovery of an invading encapsulated organism from the blood culture in a patient admitted to the hospital. RESULTS: Of the 264 patients studied, 10 had a postsplenectomy infection (3.8%); nine occurred in patients who underwent splenectomy between the ages of 0 and 5 years. Infection took place within 2 +/- 3 years (mean +/- SD) after splenectomy for the immunized patients and 11 +/- 5 days (mean +/- SD) for the nonimmunized children. A significant number of patients were admitted for an apparent respiratory infection, but no serum organisms were isolated. One died of overwhelming sepsis, but the responsible organism was not identified. CONCLUSION: Although there has not been a decrease in the number of splenectomies performed per year, the incidence of infection and mortality has decreased by 47% and 88%, respectively, with prophylaxis.
Authors: James H Wood; David A Partrick; Taru Hays; Angela Sauaia; Frederick M Karrer; Moritz M Ziegler Journal: Pediatr Surg Int Date: 2011-05-28 Impact factor: 1.827
Authors: Ram Kalpatthi; Ian D Kane; Ibrahim F Shatat; Betsy Rackoff; Deborah Disco; Sherron M Jackson Journal: Pediatr Surg Int Date: 2010-03-23 Impact factor: 1.827
Authors: B Habermalz; S Sauerland; G Decker; B Delaitre; J-F Gigot; E Leandros; K Lechner; M Rhodes; G Silecchia; A Szold; E Targarona; P Torelli; E Neugebauer Journal: Surg Endosc Date: 2008-02-22 Impact factor: 4.584
Authors: Anwar K Sheikha; Ziyan T Salih; Kalandar H Kasnazan; Mohammad K Khoshnaw; Talal Al-Maliki; Tarek A Al-Azraqi; Mubarak H Zafer Journal: Can J Surg Date: 2007-10 Impact factor: 2.089
Authors: Monica Khurana; Donna Edwards; Frederic Rescorla; Caroline Miller; Ying He; Elizabeth Sierra Potchanant; Grzegorz Nalepa Journal: Cold Spring Harb Mol Case Stud Date: 2018-10-01