[Reparative processes and immunity].

The published and author's data concerning changes in formation of antibodies to T-dependent antigen during regeneration of various organs in mammals are summarized. Significance of stress, functional transgression of the injured organs, products of tissue degradation and degree of organ tissue deficit for postoperative stimulation of antibody formation has been discussed. Interaction between the organ antigens and lymphoid tissue was shown to be important for changes of immunoreactivity. Dependence of the immune system postoperative stimulation on the organ tissue deficit is connected with the increase of the T-helpers/T-suppressors ratio in the spleen of operated animals. It has been proposed that the mechanism underlying the action of organ tissue deficit is connected with the loss of natural immunological tolerance to organospecific autoantigens.