Literature DB >> 10441801

[Malnutrition and osteoporosis].

R Rizzoli1, J P Bonjour.   

Abstract

Undernutrition, particularly protein undernutrition, contributes to the occurrence of osteoporotic fracture, by lowering bone mass and altering muscle strength. Furthermore, the rate of medical complications after fracture can also be increased by nutritional deficiency. The IGF-I system appears to be directly involved in the pathogenetic mechanisms leading to osteoporotic hip fracture in elderly and to its complications. In the presence of adequate calcium and vitamin D supplies, protein supplements increasing the intakes from low to normal, raises IGF-I levels, improves the clinical outcome after hip fracture, and attenuates the decrease in proximal femur bone mineral density in the year following the fracture. This nutritional approach is associated with a significant reduction of the stay in rehabilitation hospital. This underlines the importance of nutritional supports in preventing and healing osteoporotic fractures.

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Year:  1999        PMID: 10441801     DOI: 10.1007/s003910050178

Source DB:  PubMed          Journal:  Z Gerontol Geriatr        ISSN: 0948-6704            Impact factor:   1.281


  54 in total

1.  Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older.

Authors:  B Dawson-Hughes; S S Harris; E A Krall; G E Dallal
Journal:  N Engl J Med       Date:  1997-09-04       Impact factor: 91.245

2.  Risk factors for falls as a cause of hip fracture in women. The Northeast Hip Fracture Study Group.

Authors:  J A Grisso; J L Kelsey; B L Strom; G Y Chiu; G Maislin; L A O'Brien; S Hoffman; F Kaplan
Journal:  N Engl J Med       Date:  1991-05-09       Impact factor: 91.245

3.  Cross-cultural association between dietary animal protein and hip fracture: a hypothesis.

Authors:  B J Abelow; T R Holford; K L Insogna
Journal:  Calcif Tissue Int       Date:  1992-01       Impact factor: 4.333

Review 4.  Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group.

Authors: 
Journal:  World Health Organ Tech Rep Ser       Date:  1994

5.  Bone density and shape as determinants of bone strength in IGF-I and/or pamidronate-treated ovariectomized rats.

Authors:  P Ammann; R Rizzoli; J M Meyer; J P Bonjour
Journal:  Osteoporos Int       Date:  1996       Impact factor: 4.507

6.  Increased serum clearance and degradation of 125I-labeled IGF-I in protein-restricted rats.

Authors:  J P Thissen; M L Davenport; J B Pucilowska; M V Miles; L E Underwood
Journal:  Am J Physiol       Date:  1992-04

7.  A prospective study on socioeconomic aspects of fracture of the proximal femur.

Authors:  M A Schürch; R Rizzoli; B Mermillod; H Vasey; J P Michel; J P Bonjour
Journal:  J Bone Miner Res       Date:  1996-12       Impact factor: 6.741

8.  Differential regulation of IGF-1 and IGF-binding protein-1 by dietary composition in humans.

Authors:  V C Musey; S Goldstein; P K Farmer; P B Moore; L S Phillips
Journal:  Am J Med Sci       Date:  1993-03       Impact factor: 2.378

9.  Arginine increases insulin-like growth factor-I production and collagen synthesis in osteoblast-like cells.

Authors:  T Chevalley; R Rizzoli; D Manen; J Caverzasio; J P Bonjour
Journal:  Bone       Date:  1998-08       Impact factor: 4.398

10.  Epidemiology of osteoporosis.

Authors:  C Cooper; L J Melton
Journal:  Trends Endocrinol Metab       Date:  1992-08       Impact factor: 12.015

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