Literature DB >> 10441786

Pharmacological investigation of Ocimum gratissimum in rodents.

P I Aziba1, D Bass, Y Elegbe.   

Abstract

The pharmacological activities were screened of aqueous extracts of Ocimum gratissimum in isolated rabbit jejunum (IRJ); rat stomach strip (RSS); and also its analgesic properties in mice. The extract caused a dose dependent inhibition of the rabbit jejunum spontaneous pendular movement. The blocking effect on acetylcholine induced contraction was non-competitive in the rat stomach strip since maximum contractions were suppressed and no parallel shift was observed in the curve. The result of the analgesic study showed that the extract evoked a prolongation of reaction time of 85% ( p < 0. 05) over 20 min observation time with no overt signs of toxicity. These results suggest the presence of analgesic and spasmolytic activities. Copyright 1999 John Wiley & Sons, Ltd.

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Year:  1999        PMID： 10441786     DOI： 10.1002/(sici)1099-1573(199908/09)13:5<427::aid-ptr467>3.0.co;2-t

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  8 in total

1.  Differential Nutrition-Health Properties of Ocimum basilicum Leaf and Stem Extracts.

Authors:  Aicha Bensaid; Frederic Boudard; Adrien Servent; Sylvie Morel; Karine Portet; Caroline Guzman; Manon Vitou; Florence Bichon; Patrick Poucheret
Journal:  Foods       Date:  2022-06-09

2.  Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H(2)O(2)-Induced Cell Apoptosis through Akt Signalling.

Authors:  Mu-Jang Lee; Han-Min Chen; Bor-Show Tzang; Chiu-Wen Lin; Chau-Jong Wang; Jer-Yuh Liu; Shao-Hsuan Kao
Journal:  Evid Based Complement Alternat Med       Date:  2010-08-30       Impact factor: 2.629

3.  Anticonvulsant and anxiolytic evaluation of leaf extracts of Ocimum gratissimum, a culinary herb.

Authors:  C O Okoli; A C Ezike; O C Agwagah; P A Akah
Journal:  Pharmacognosy Res       Date:  2010-01

4.  Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters.

Authors:  Pei-Yu Chao; James A Lin; Wei-Jen Ting; Hsueh-Hui Lee; Kuanghui Hsieh; Yung-Wei Chiu; Te-Jen Lai; Jin-Ming Hwang; Je-rYuh Liu; Chih-Yang Huang
Journal:  Int J Med Sci       Date:  2016-10-18       Impact factor: 3.738

5.  Amelioration of estrogen-deficiency-induced obesity by Ocimum gratissimum.

Authors:  Pei-Yu Chao; Tsay-I Chiang; I-Chang Chang; Fang-Ling Tsai; Hsueh-Hui Lee; Kuanghui Hsieh; Yung-Wei Chiu; Te-Jen Lai; Jer-Yuh Liu; Li-Sung Hsu; Yang-Chia Shih
Journal:  Int J Med Sci       Date:  2017-07-20       Impact factor: 3.738

6.  Aqueous Ocimum gratissimum extract induces cell apoptosis in human hepatocellular carcinoma cells.

Authors:  Chen-Cheng Huang; Jin-Ming Hwang; Jen-Hsiang Tsai; Jing Huei Chen; Ho Lin; Geng-Jhih Lin; Hsin-Ling Yang; Jer-Yuh Liu; Chiou-Ying Yang; Je-Chiuan Ye
Journal:  Int J Med Sci       Date:  2020-01-18       Impact factor: 3.738

Review 7.  A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.).

Authors:  Ositadinma Chinyere Ugbogu; Okezie Emmanuel; Grace Oka Agi; Chibuike Ibe; Celestine Nwabu Ekweogu; Victor Chibueze Ude; Miracle Ebubechi Uche; Rachel Oluchukwu Nnanna; Eziuche Amadike Ugbogu
Journal:  Heliyon       Date:  2021-11-25

8.  Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana.

Authors:  Patrick Amoateng; Emmanuel Quansah; Thomas K Karikari; Alex Asase; Dorcas Osei-Safo; Kennedy Kwami Edem Kukuia; Isaac Kingsley Amponsah; Alexander K Nyarko
Journal:  Evid Based Complement Alternat Med       Date:  2018-12-20       Impact factor: 2.629
  8 in total

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