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Literature DB >> 10441545

Activin as a morphogen in Xenopus mesoderm induction.

Abstract

Activin, a member of the Transforming Growth Factor beta (TGF-beta) superfamily, can behave as a morphogen in cells of the early Xenopus embryo by inducing a range of mesodermal genes in a concentration-dependent manner. This review examines the behaviour of activin as it forms a morphogen gradient. It also discusses how a cell can perceive its position in a concentration gradient in order to activate appropriate mesodermal gene responses. Copyright 1999 Academic Press.

Entities: Gene Species

Mesh：

Substances：
Ligands
Activins
Inhibins

Year: 1999 PMID： 10441545 DOI： 10.1006/scdb.1999.0307

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

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Cited

18 in total

Review 1. The Spemann organizer and embryonic head induction.

Authors: C Niehrs
Journal: EMBO J Date: 2001-02-15 Impact factor: 11.598

2. The pattern of nodal morphogen signaling is shaped by co-receptor expression.

Authors: Nathan D Lord; Adam N Carte; Philip B Abitua; Alexander F Schier
Journal: Elife Date: 2021-05-26 Impact factor: 8.140

Review 3. Mechanical Forces and Growth in Animal Tissues.

Authors: Loïc LeGoff; Thomas Lecuit
Journal: Cold Spring Harb Perspect Biol Date: 2015-08-10 Impact factor: 10.005

Review 4. Understanding how morphogens work.

Authors: J C Smith; A Hagemann; Y Saka; P H Williams
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2008-04-12 Impact factor: 6.237

Review 5. TGF-β signaling in C. elegans.

Authors: Tina L Gumienny; Cathy Savage-Dunn
Journal: WormBook Date: 2013-07-10

Activin as a morphogen in Xenopus mesoderm induction.

Review 1. The Spemann organizer and embryonic head induction.

2. The pattern of nodal morphogen signaling is shaped by co-receptor expression.

Review 3. Mechanical Forces and Growth in Animal Tissues.

Review 4. Understanding how morphogens work.

Review 5. TGF-β signaling in C. elegans.

6. Activins and follistatins: Emerging roles in liver physiology and cancer.

7. Activin betaC and betaE genes are not essential for mouse liver growth, differentiation, and regeneration.

8. Building a morphogen gradient without diffusion in a growing tissue.

Review 9. Activins and activin antagonists in hepatocellular carcinoma.

10. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.