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Literature DB >> 10441007

Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma.

W V Yotov¹, H Hamel, G E Rivard, M A Champagne, P A Russo, J M Leclerc, M L Bernstein, E Levy.

Abstract

We studied the involvement of PRIM1 in osteosarcoma by differential display, Northern and Southern hybridization, as well as fluorescence in situ hybridization (FISH) on interphase nuclei. In total, 22 pediatric oncology specimens were tested. PRIM1 was found to be amplified in 41% of the samples. PRIM1 is coamplified with the core 12q13 amplicon genes CDK4, SAS, and OS9, and was physically mapped very close to them. PRIM1 is therefore a new candidate for the role of a major target gene of 12q13 amplifications in human cancers. Genes Chromosomes Cancer 26:62-69, 1999. Copyright 1999 Wiley-Liss, Inc.

Entities: Disease Gene Species

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Substances：

Year: 1999 PMID： 10441007 DOI： 10.1002/(sici)1098-2264(199909)26:1<62::aid-gcc9>3.0.co;2-f

Source DB: PubMed Journal: Genes Chromosomes Cancer ISSN： 1045-2257 Impact factor: 5.006

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Cited

16 in total

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5. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.

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Amplifications of DNA primase 1 (PRIM1) in human osteosarcoma.

1. Truncation of histone H2A's C-terminal tail, as is typical for Ni(II)-assisted specific peptide bond hydrolysis, has gene expression altering effects.

2. Monoallelic deletion of the p53 gene through chromosomal translocation in a small cell osteosarcoma.

Review 3. Osteosarcoma development and stem cell differentiation.

Review 4. Translational biology of osteosarcoma.

5. Subunits of the DNA polymerase alpha-primase complex promote Notch-mediated proliferation with discrete and shared functions in C. elegans germline.

Review 6. Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies.

7. The genetics of osteosarcoma.

Review 8. Structures to complement the archaeo-eukaryotic primases catalytic cycle description: What's next?

9. A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers.

10. Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma.